PNPLA8

PNPLA8
Identifiers
Aliases	PNPLA8, IPLA2(GAMMA), IPLA2-2, IPLA2G, iPLA2gamma, MMLA, PNPLA-gamma, patatin like phospholipase domain containing 8
External IDs	OMIM: 612123; MGI: 1914702; HomoloGene: 12136; GeneCards: PNPLA8; OMA:PNPLA8 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	108,569,666 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	44,369,315 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; pancreatic epithelial cell; ; tibialis anterior muscle; ; deltoid muscle; ; entorhinal cortex; ; myocardium of left ventricle; ; pars compacta; ; right ventricle; ; pars reticulata; ; corpus callosum;
	Top expressed in
	muscle of thigh; ; brown adipose tissue; ; intercostal muscle; ; vastus lateralis muscle; ; temporal muscle; ; myocardium of ventricle; ; sternocleidomastoid muscle; ; triceps brachii muscle; ; mammary gland; ; soleus muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	lysophospholipase activity; calcium-independent phospholipase A2 activity; hydrolase activity; ATP binding; phospholipase A2 activity;
Cellular component	cytoplasm; integral component of membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; Golgi membrane; peroxisomal membrane; peroxisome; intracellular anatomical structure; endoplasmic reticulum; perinuclear region of cytoplasm;
Biological process	linoleic acid metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine catabolic process; lipid metabolism; cell death; fatty acid metabolic process; lipid catabolic process; phosphatidylethanolamine catabolic process; prostaglandin biosynthetic process; metabolism; arachidonic acid metabolic process; phosphatidylcholine acyl-chain remodeling; arachidonic acid secretion;
	Sources:Amigo / QuickGO
Orthologs
	50640
	67452
	ENSG00000135241
	ENSMUSG00000036257
	Q9NP80
	Q8K1N1
NM_001256007; NM_001256008; NM_001256009; NM_001256010; NM_001256011;
	NM_015723
	NM_026164
NP_001242936; NP_001242937; NP_001242938; NP_001242939; NP_001242940;
	NP_056538
	NP_080440
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium-independent phospholipase A2-gamma is an enzyme that in humans is encoded by the PNPLA8 gene.^[5]^[6]^[7]^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135241 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036257 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mancuso DJ, Jenkins CM, Gross RW (May 2000). "The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2)". J Biol Chem. 275 (14): 9937–45. doi:10.1074/jbc.275.14.9937. PMID 10744668.
^ Tanaka H, Takeya R, Sumimoto H (Jul 2000). "A novel intracellular membrane-bound calcium-independent phospholipase A(2)". Biochem Biophys Res Commun. 272 (2): 320–6. doi:10.1006/bbrc.2000.2776. PMID 10833412.
^ Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (Aug 2006). "Characterization of the human patatin-like phospholipase family". J Lipid Res. 47 (9): 1940–9. doi:10.1194/jlr.M600185-JLR200. PMID 16799181.
^ Kienesberger PC, Oberer M, Lass A, Zechner R (Apr 2009). "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions". J Lipid Res. 50 Suppl (Supplement): S63–8. doi:10.1194/jlr.R800082-JLR200. PMC 2674697. PMID 19029121.
^ "Entrez Gene: PNPLA8 patatin-like phospholipase domain containing 8".

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wiemann S, Arlt D, Huber W (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Murakami M, Masuda S, Ueda-Semmyo K (2005). "Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2". J. Biol. Chem. 280 (14): 14028–41. doi:10.1074/jbc.M413766200. PMID 15695510.
Mehrle A, Rosenfelder H, Schupp I (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135241 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036257 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10744668-5] Mancuso DJ, Jenkins CM, Gross RW (May 2000). "The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2)". J Biol Chem. 275 (14): 9937–45. doi:10.1074/jbc.275.14.9937. PMID 10744668.

[pmid10833412-6] Tanaka H, Takeya R, Sumimoto H (Jul 2000). "A novel intracellular membrane-bound calcium-independent phospholipase A(2)". Biochem Biophys Res Commun. 272 (2): 320–6. doi:10.1006/bbrc.2000.2776. PMID 10833412.

[pmid16799181-7] Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (Aug 2006). "Characterization of the human patatin-like phospholipase family". J Lipid Res. 47 (9): 1940–9. doi:10.1194/jlr.M600185-JLR200. PMID 16799181.

[pmid19029121-8] Kienesberger PC, Oberer M, Lass A, Zechner R (Apr 2009). "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions". J Lipid Res. 50 Suppl (Supplement): S63–8. doi:10.1194/jlr.R800082-JLR200. PMC 2674697. PMID 19029121.

[entrez-9] "Entrez Gene: PNPLA8 patatin-like phospholipase domain containing 8".

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References

Further reading