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PODXL2

From Wikipedia, the free encyclopedia
PODXL2
Identifiers
AliasesPODXL2, EG, PODLX2, podocalyxin like 2
External IDsOMIM: 616627; MGI: 2442488; HomoloGene: 9254; GeneCards: PODXL2; OMA:PODXL2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015720

NM_176973
NM_001347327
NM_001364575

RefSeq (protein)

NP_056535

Location (UCSC)Chr 3: 127.63 – 127.67 MbChr 6: 88.84 – 88.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Podocalyxin like 2 is a protein that in humans is encoded by the PODXL2 gene. [5]

Structure

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This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012].


Function

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Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114631Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033152Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Podocalyxin like 2". Retrieved 2017-10-11.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.