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POLR3K

From Wikipedia, the free encyclopedia
POLR3K
Identifiers
AliasesPOLR3K, C11, C11-RNP3, RPC10, RPC11, RPC12.5, My010, polymerase (RNA) III subunit K, RNA polymerase III subunit K, HLD21
External IDsOMIM: 606007; MGI: 1914255; HomoloGene: 5610; GeneCards: POLR3K; OMA:POLR3K - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016310

NM_025901

RefSeq (protein)

NP_057394

NP_080177

Location (UCSC)Chr 16: 0.05 – 0.05 MbChr 2: 181.51 – 181.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA-directed RNA polymerase III subunit RPC10 is an enzyme that in humans is encoded by the POLR3K gene.[5][6][7]

This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes.

The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000161980Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038628Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chedin S, Riva M, Schultz P, Sentenac A, Carles C (Jan 1999). "The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination". Genes Dev. 12 (24): 3857–71. doi:10.1101/gad.12.24.3857. PMC 317263. PMID 9869639.
  6. ^ Spakovskii GV, Lebedenko EN (Mar 1999). "[Molecular identification and characteristics of hRPC11, the smallest specific subunit of human RNA polymerase III]". Bioorg Khim. 24 (11): 877–80. PMID 10079944.
  7. ^ a b "Entrez Gene: POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa".

Further reading

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