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PPAP2A

From Wikipedia, the free encyclopedia
PLPP1
Identifiers
AliasesPLPP1, LLP1a, LPP1, PAP-2a, PAP2, PPAP2A, phospholipid phosphatase 1
External IDsOMIM: 607124; MGI: 108412; HomoloGene: 7484; GeneCards: PLPP1; OMA:PLPP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003711
NM_176895

NM_008247
NM_008903

RefSeq (protein)

NP_003702
NP_795714

NP_032273
NP_032929

Location (UCSC)Chr 5: 55.42 – 55.53 MbChr 13: 112.94 – 113 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lipid phosphate phosphohydrolase 1 also known as phosphatidic acid phosphatase 2a is an enzyme that in humans is encoded by the PPAP2A gene.[5][6]

Function

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Lipid phosphate phosphohydrolase 1 is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000067113Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021759Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kai M, Wada I, Imai S, Sakane F, Kanoh H (Oct 1997). "Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase". J Biol Chem. 272 (39): 24572–24578. doi:10.1074/jbc.272.39.24572. PMID 9305923.
  6. ^ a b "Entrez Gene: PPAP2A phosphatidic acid phosphatase type 2A".

Further reading

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