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PPIL2

From Wikipedia, the free encyclopedia
PPIL2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPIL2, CYC4, CYP60, Cyp-60, UBOX7, hCyP-60, peptidylprolyl isomerase like 2
External IDsOMIM: 607588; MGI: 2447857; HomoloGene: 8643; GeneCards: PPIL2; OMA:PPIL2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014337
NM_148175
NM_148176
NM_001317996

NM_001252444
NM_001252445
NM_144954
NM_001356386

RefSeq (protein)

NP_001304925
NP_055152
NP_680480
NP_680481

NP_001239373
NP_001239374
NP_659203
NP_001343315

Location (UCSC)Chr 22: 21.67 – 21.7 MbChr 16: 16.9 – 16.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peptidyl-prolyl cis-trans isomerase-like 2 is an enzyme that in humans is encoded by the PPIL2 gene.[5][6]

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100023Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022771Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  6. ^ a b "Entrez Gene: PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2".

Further reading

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