From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Protein arginine N-methyltransferase 3 is an enzyme that in humans is encoded by the PRMT3 gene .[ 5] [ 6]
PRMT3 has been shown to interact with RPS2 .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000185238 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030505 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Tang J, Gary JD, Clarke S, Herschman HR (July 1998). "PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation" . The Journal of Biological Chemistry . 273 (27): 16935–45. doi :10.1074/jbc.273.27.16935 PMID 9642256 . ^ "Entrez Gene: PRMT3 protein arginine methyltransferase 3" .^ Choi S, Jung CR, Kim JY, Im DS (September 2008). "PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex". Biochimica et Biophysica Acta (BBA) - General Subjects . 1780 (9): 1062–9. doi :10.1016/j.bbagen.2008.05.010 . PMID 18573314 .
Singh V, Miranda TB, Jiang W, Frankel A, Roemer ME, Robb VA, et al. (October 2004). "DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo" . Oncogene . 23 (47): 7761–71. doi :10.1038/sj.onc.1208057 PMID 15334060 . Bachand F, Silver PA (July 2004). "PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits" . The EMBO Journal . 23 (13): 2641–50. doi :10.1038/sj.emboj.7600265 . PMC 449775 PMID 15175657 . Smith JJ, Rücknagel KP, Schierhorn A, Tang J, Nemeth A, Linder M, et al. (May 1999). "Unusual sites of arginine methylation in Poly(A)-binding protein II and in vitro methylation by protein arginine methyltransferases PRMT1 and PRMT3" . The Journal of Biological Chemistry . 274 (19): 13229–34. doi :10.1074/jbc.274.19.13229 PMID 10224081 .
PDB gallery
1f3l : CRYSTAL STRUCTURE OF THE CONSERVED CORE OF PROTEIN ARGININE METHYLTRANSFERASE PRMT3
1wir : Solution structure of the C2H2 zinc finger domain of the protein arginine N-methyltransferase 3 from Mus musculus
2fyt : Human HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae) protein
