Peripolar cell

Peripolar cells are specialized epithelial cells. Peripolar cells are situated within Bowman's capsule at its vascular pole. This location is where the parietal and visceral layers of Bowman's capsule converge, placing the peripolar cells in close proximity to the glomerular capillaries. These cells was discovered at the vascular pole of the sheep glomerulus. The cells contain numerous cytoplasmic granules. The granules in peripolar cells are secretory, and the cells show features of secretory epithelial cells, although no exocytosis was observed. By secreting specific molecules, they may influence the composition of the filtrate and the reabsorption processes in the renal tubules. There is also ongoing research into the potential role of peripolar cells in the juxtaglomerular apparatus (JGA). The number, size, and appearance of peripolar cells can vary significantly across different mammalian species.^[1]^[2]

References

^ Gardiner, D. S.; More, I. A.; Lindop, G. B. (1986). "The granular peripolar cell of the human glomerulus: an ultrastructural study". Journal of Anatomy. 146: 31–43. PMC 1166522. PMID 3693060.
^ Gibson, I. W.; Gardiner, D. S.; Downie, I.; Downie, T. T.; More, I. A. R.; Lindop, G. B. M. (1994). "A comparative study of the glomerular peripolar cell and the renin-secreting cell in twelve mammalian species". Cell & Tissue Research. 277 (2): 385–390. doi:10.1007/BF00327786. PMID 8082126.

[1] Gardiner, D. S.; More, I. A.; Lindop, G. B. (1986). "The granular peripolar cell of the human glomerulus: an ultrastructural study". Journal of Anatomy. 146: 31–43. PMC 1166522. PMID 3693060.

[2] Gibson, I. W.; Gardiner, D. S.; Downie, I.; Downie, T. T.; More, I. A. R.; Lindop, G. B. M. (1994). "A comparative study of the glomerular peripolar cell and the renin-secreting cell in twelve mammalian species". Cell & Tissue Research. 277 (2): 385–390. doi:10.1007/BF00327786. PMID 8082126.

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