PhTx-1

PhTx-1 is a toxic fraction isolated from the venom of the Brazilian wandering spider Phoneutria nigriventer.

Composition and Target

PhTx-1 has as its main toxin PnTx-1, with a molecular mass of 8,594.6 Da, composed of 77 aminoacid residues, 14 of which are cysteines.^[1] PnTx-1, also known as Tx1, exerts an inhibitory effect on neuronal sodium channels (Nav1.2).^[2] This component is considered highly pathogenic for primates.

References

^ Resende, Rodrigo R. (2015-01-01). Biotecnologia aplicada à saúde - vol. 1: fundamentos e aplicações (in European Portuguese). Editora Blucher. ISBN 978-85-212-0897-6.
^ Weiss, Marcelo Barros; Paiva, Jorge Wilson Souza (2018-10-10). Acidentes com Animais Peçonhentos (in Brazilian Portuguese). Thieme Revinter Publicações LTDA. ISBN 978-85-5465-084-1.

[1] Resende, Rodrigo R. (2015-01-01). Biotecnologia aplicada à saúde - vol. 1: fundamentos e aplicações (in European Portuguese). Editora Blucher. ISBN 978-85-212-0897-6.

[2] Weiss, Marcelo Barros; Paiva, Jorge Wilson Souza (2018-10-10). Acidentes com Animais Peçonhentos (in Brazilian Portuguese). Thieme Revinter Publicações LTDA. ISBN 978-85-5465-084-1.

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