Jump to content

Protein geranylgeranyltransferase type I subunit beta

From Wikipedia, the free encyclopedia
PGGT1B
Identifiers
AliasesPGGT1B, BGGI, GGTI, protein geranylgeranyltransferase type I subunit beta
External IDsOMIM: 602031; MGI: 1917514; HomoloGene: 3685; GeneCards: PGGT1B; OMA:PGGT1B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005023

NM_172627

RefSeq (protein)

NP_005014

NP_766215

Location (UCSC)Chr 5: 115.2 – 115.26 MbChr 18: 46.37 – 46.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein geranylgeranyltransferase type I subunit beta is a protein that in humans is encoded by the PGGT1B gene. [5]

Function

[edit]

Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010].

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164219Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024477Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Protein geranylgeranyltransferase type I subunit beta". Retrieved 2018-09-21.

Further reading

[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.