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Pseudaminic acid synthase

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Pseudaminic acid synthase
Identifiers
EC no.2.5.1.97
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
PRIAMprofile
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Pseudaminic acid synthase (EC 2.5.1.97, PseI, NeuB3) is an enzyme with systematic name phosphoenolpyruvate:2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose transferase (phosphate-hydrolysing, 2,7-acetylamino-transferring, 2-carboxy-2-oxoethyl-forming).[1] This enzyme catalyses the following chemical reaction

phosphoenolpyruvate + 2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose + H2O 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid + phosphate

The enzyme requires a divalent metal ion, preferably Mn2+ and Co2+.

References

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  1. ^ Chou WK, Dick S, Wakarchuk WW, Tanner ME (October 2005). "Identification and characterization of NeuB3 from Campylobacter jejuni as a pseudaminic acid synthase". The Journal of Biological Chemistry. 280 (43): 35922–8. doi:10.1074/jbc.M507483200. PMID 16120604.
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