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REPS2

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REPS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesREPS2, POB1, RALBP1 associated Eps domain containing 2
External IDsOMIM: 300317; MGI: 2663511; HomoloGene: 31255; GeneCards: REPS2; OMA:REPS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001080975
NM_004726

NM_001290633
NM_178256
NM_001359102
NM_001359103
NM_001359104

RefSeq (protein)

NP_001074444
NP_004717

Location (UCSC)Chr X: 16.95 – 17.15 MbChr X: 161.19 – 161.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RalBP1-associated Eps domain-containing protein 2 is a protein that in humans is encoded by the REPS2 gene.[5][6][7]


Function

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The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.[7]

Interactions

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REPS2 has been shown to interact with EPN1,[8] EPS15[9] and RALBP1.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169891Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040855Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Ikeda M, Ishida O, Hinoi T, Kishida S, Kikuchi A (February 1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral". J Biol Chem. 273 (2): 814–21. doi:10.1074/jbc.273.2.814. PMID 9422736.
  6. ^ Koshiba S, Kigawa T, Iwahara J, Kikuchi A, Yokoyama S (February 1999). "Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1)". FEBS Lett. 442 (2–3): 138–42. doi:10.1016/S0014-5793(98)01644-5. PMID 9928989.
  7. ^ a b "Entrez Gene: REPS2 RALBP1 associated Eps domain containing 2".
  8. ^ Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A (October 1999). "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene. 18 (43): 5915–22. doi:10.1038/sj.onc.1202974. PMID 10557078. S2CID 23390428.
  9. ^ Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A (July 1999). "Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors". EMBO J. 18 (13): 3629–42. doi:10.1093/emboj/18.13.3629. PMC 1171441. PMID 10393179.

Further reading

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