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RFWD2

From Wikipedia, the free encyclopedia

COP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCOP1, RNF200, ring finger and WD repeat domain 2, E3 ubiquitin ligase, RFWD2, COP1 E3 ubiquitin ligase, FAP78, CFAP78
External IDsOMIM: 608067; MGI: 1347046; HomoloGene: 115565; GeneCards: COP1; OMA:COP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001001740
NM_001286644
NM_022457

NM_011931
NM_001360878

RefSeq (protein)

NP_001001740
NP_001273573
NP_071902

NP_036061
NP_001347807

Location (UCSC)Chr 1: 175.94 – 176.21 MbChr 1: 159.06 – 159.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase RFWD2 is an enzyme that in humans is encoded by the RFWD2 gene.[5][6]

Interactions

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RFWD2 has been shown to interact with C-jun.[7][8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143207Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040782Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang H, Kang D, Deng XW, Wei N (Sep 1999). "Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1". Curr Biol. 9 (13): 711–4. Bibcode:1999CBio....9..711W. doi:10.1016/S0960-9822(99)80314-5. PMID 10395541. S2CID 2822539.
  6. ^ "Entrez Gene: RFWD2 ring finger and WD repeat domain 2".
  7. ^ Wertz IE, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM (Feb 2004). "Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase" (PDF). Science. 303 (5662): 1371–4. Bibcode:2004Sci...303.1371W. doi:10.1126/science.1093549. PMID 14739464. S2CID 40501515.
  8. ^ Bianchi E, Denti S, Catena R, Rossetti G, Polo S, Gasparian S, Putignano S, Rogge L, Pardi R (May 2003). "Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity". J. Biol. Chem. 278 (22): 19682–90. doi:10.1074/jbc.M212681200. hdl:2434/518351. PMID 12615916.

Further reading

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