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RNF139

From Wikipedia, the free encyclopedia

RNF139
Identifiers
AliasesRNF139, HRCA1, RCA1, TRC8, ring finger protein 139
External IDsOMIM: 603046; MGI: 1923091; HomoloGene: 5222; GeneCards: RNF139; OMA:RNF139 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007218

NM_175226

RefSeq (protein)

NP_009149

NP_780435

Location (UCSC)Chr 8: 124.47 – 124.49 MbChr 15: 58.76 – 58.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RING finger protein 139, also known as TRC8, is a protein that in humans is encoded by the RNF139 gene.[5][6]

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medullary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP].[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170881Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037075Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA (Sep 1998). "The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8". Proc Natl Acad Sci U S A. 95 (16): 9572–7. Bibcode:1998PNAS...95.9572G. doi:10.1073/pnas.95.16.9572. PMC 21380. PMID 9689122.
  6. ^ a b "Entrez Gene: RNF139 ring finger protein 139".

Further reading

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