From Wikipedia, the free encyclopedia
Nuclear receptors that bind to retinoids
Retinoid receptors are type II nuclear receptors (a class of proteins) that bind to retinoids. When bound to a retinoid, they act as transcription factors, altering the expression of genes with corresponding response elements.
Subtypes include:
|
|---|
(1) Basic domains |
|---|
| (1.1) Basic leucine zipper (bZIP) | |
|---|
| (1.2) Basic helix-loop-helix (bHLH) | | Group A | |
|---|
| Group B | |
|---|
Group C
bHLH-PAS | |
|---|
| Group D | |
|---|
| Group E | |
|---|
Group F
bHLH-COE | |
|---|
|
|---|
| (1.3) bHLH-ZIP | |
|---|
| (1.4) NF-1 | |
|---|
| (1.5) RF-X | |
|---|
| (1.6) Basic helix-span-helix (bHSH) | |
|---|
|
|
(2) Zinc finger DNA-binding domains |
|---|
| (2.1) Nuclear receptor (Cys4) | | subfamily 1 | |
|---|
| subfamily 2 | |
|---|
| subfamily 3 | |
|---|
| subfamily 4 | |
|---|
| subfamily 5 | |
|---|
| subfamily 6 | |
|---|
| subfamily 0 | |
|---|
|
|---|
| (2.2) Other Cys4 | |
|---|
| (2.3) Cys2His2 | |
|---|
| (2.4) Cys6 | |
|---|
| (2.5) Alternating composition | |
|---|
| (2.6) WRKY | |
|---|
|
|
|
(4) β-Scaffold factors with minor groove contacts |
|---|
|
|
(0) Other transcription factors |
|---|
|
|
|
|
|---|
| RARTooltip Retinoic acid receptor |
- Retinoic acid metabolism inhibitors: Liarozole
|
|---|
| RXRTooltip Retinoid X receptor | |
|---|
|
