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S-methyl-5-thioribose kinase

From Wikipedia, the free encyclopedia
S-methyl-5-thioribose kinase
Identifiers
EC no.2.7.1.100
CAS no.68247-56-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a S-methyl-5-thioribose kinase (EC 2.7.1.100) is an enzyme that catalyzes the chemical reaction

ATP + S-methyl-5-thio-D-ribose ADP + S-methyl-5-thio-alpha-D-ribose 1-phosphate

Thus, the two substrates of this enzyme are ATP and S-methyl-5-thio-D-ribose, whereas its two products are ADP and S-methyl-5-thio-alpha-D-ribose 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:S-methylmethyl-5-thio-D-ribose 1-phosphotransferase. Other names in common use include 5-methylthioribose kinase (phosphorylating), methylthioribose kinase, 5-methylthioribose kinase, and ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase. This enzyme participates in methionine metabolism.

Structural studies

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As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 2OLC, 2PU8, 2PUI, 2PUL, 2PUN, and 2PUP.

References

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  • Ferro AJ, Barrett A, Shapiro SK (1978). "5-Methylthioribose kinase. A new enzyme involved in the formation of methionine from 5-methylthioribose". J. Biol. Chem. 253 (17): 6021–5. doi:10.1016/S0021-9258(17)34573-8. PMID 210167.
  • Guranowski A (1983). "Plant 5-methylthioribose kinase". Plant Physiol. 71 (4): 932–935. doi:10.1104/pp.71.4.932. PMC 1066146. PMID 16662931.