SB 203580
Appearance
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Names | |
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Preferred IUPAC name
4-{4-(4-Fluorophenyl)-2-[4-(methanesulfinyl)phenyl]-1H-imidazol-5-yl}pyridine | |
Other names
RWJ-64809;
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Identifiers | |
3D model (JSmol)
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.214.849 |
EC Number |
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PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C21H16FN3OS | |
Molar mass | 377.43 g/mol |
Appearance | White to off-white solid |
Solubility in DMSO | 50 mg/mL |
Hazards | |
GHS labelling: | |
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Danger | |
H302, H318 | |
P264, P270, P280, P301+P312, P305+P351+P338, P310, P330, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27. At low concentrations, it does not inhibit JNK activity. SB-203580 was recently assigned the INN Adezamapimod, and is currently in phase 2 clinical trials to prevent post-operative tissue adhesion.
References
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