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SDK2

From Wikipedia, the free encyclopedia
SDK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSDK2, sidekick cell adhesion molecule 2
External IDsOMIM: 607217; MGI: 2443847; HomoloGene: 10406; GeneCards: SDK2; OMA:SDK2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001144952
NM_019064

NM_172800

RefSeq (protein)

NP_001138424

NP_766388

Location (UCSC)Chr 17: 73.33 – 73.64 MbChr 11: 113.67 – 113.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein sidekick-2 is a protein that in humans is encoded by the SDK2 gene.[5][6][7][8]

Function

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The protein encoded by this gene is a member of the immunoglobulin superfamily.[7] The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus has been observed but the full-length nature of additional variants has not yet been determined.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000069188Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041592Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "OMIM: SIDEKICK CELL ADHESION MOLECULE 2; SDK2".
  6. ^ Yamagata M, Weiner JA, Sanes JR (Sep 2002). "Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina". Cell. 110 (5): 649–60. doi:10.1016/S0092-8674(02)00910-8. PMID 12230981. S2CID 7650760.
  7. ^ a b Yamagata, M. (2020). "Structure and Functions of Sidekicks". Frontiers in Molecular Neuroscience. 13: 139. doi:10.3389/fnmol.2020.00139. PMC 7479261. PMID 32982686.
  8. ^ a b "Entrez Gene: SDK2 sidekick homolog 2 (chicken)".

Further reading

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