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SEMG2

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SEMG2
Identifiers
AliasesSEMG2, SGII, semenogelin II, semenogelin 2
External IDsOMIM: 182141; HomoloGene: 129832; GeneCards: SEMG2; OMA:SEMG2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003008

n/a

RefSeq (protein)

NP_002999

n/a

Location (UCSC)Chr 20: 45.22 – 45.22 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Semenogelin-2 is a protein that in humans is encoded by the SEMG2 gene.[3][4][5]

The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20.[5]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124157Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Ulvsback M, Lazure C, Lilja H, Spurr NK, Rao VV, Loffler C, Hansmann I, Lundwall A (Oct 1992). "Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20". J Biol Chem. 267 (25): 18080–4. doi:10.1016/S0021-9258(19)37155-8. PMID 1517240.
  4. ^ Peter A, Lilja H, Lundwall A, Malm J (Apr 1998). "Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase". Eur J Biochem. 252 (2): 216–21. doi:10.1046/j.1432-1327.1998.2520216.x. PMID 9523691.
  5. ^ a b "Entrez Gene: SEMG2 semenogelin II".

Further reading

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