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SEPW1

From Wikipedia, the free encyclopedia

SELENOW
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSELENOW, selW, SEPW1, selenoprotein W, 1, selenoprotein W
External IDsOMIM: 603235; MGI: 1100878; HomoloGene: 2263; GeneCards: SELENOW; OMA:SELENOW - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003009

NM_009156

RefSeq (protein)

NP_003000

NP_033182

Location (UCSC)Chr 19: 47.78 – 47.78 MbChr 7: 15.65 – 15.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Selenoprotein W is a protein that in humans is encoded by the SEPW1 gene.[5][6]

Function

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This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178980Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041571Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gu QP, Beilstein MA, Vendeland SC, Lugade A, Ream W, Whanger PD (July 1997). "Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species". Gene. 193 (2): 187–96. doi:10.1016/S0378-1119(97)00113-3. PMID 9256076.
  6. ^ a b "Entrez Gene: SEPW1 selenoprotein W, 1".

Further reading

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[edit]
  • Overview of all the structural information available in the PDB for UniProt: P63300 (Mouse Selenoprotein W) at the PDBe-KB.