Jump to content

SETDB1

From Wikipedia, the free encyclopedia
SETDB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSETDB1, ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21, SET domain bifurcated 1, SET domain bifurcated histone lysine methyltransferase 1
External IDsOMIM: 604396; MGI: 1934229; HomoloGene: 32157; GeneCards: SETDB1; OMA:SETDB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145415
NM_001243491
NM_012432
NM_001366417
NM_001366418

NM_001163641
NM_001163642
NM_018877

RefSeq (protein)

NP_001138887
NP_001230420
NP_036564
NP_001353346
NP_001353347

n/a

Location (UCSC)Chr 1: 150.93 – 150.96 MbChr 3: 95.23 – 95.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone-lysine N-methyltransferase SETDB1 is an enzyme that in humans is encoded by the SETDB1 gene.[5][6] SETDB1 is also known as KMT1E or H3K9 methyltransferase ESET.

Function

[edit]

The SET domain is a highly conserved, approximately 150-amino acid motif implicated in the modulation of chromatin structure. It was originally identified as part of a larger conserved region present in the Drosophila Trithorax protein and was subsequently identified in the Drosophila Su(var)3-9 and 'Enhancer of zeste' proteins, from which the acronym SET is derived. Studies have suggested that the SET domain may be a signature of proteins that modulate transcriptionally active or repressed chromatin states through chromatin remodeling activities.[6]

Interactions

[edit]

SETDB1 has been shown to interact with TRIM28.[7]>

See also

[edit]
  • SETD1A, a protein that is highly homologous to SETDB1

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143379Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015697Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Harte PJ, Wu W, Carrasquillo MM, Matera AG (June 1999). "Assignment of a novel bifurcated SET domain gene, SETDB1, to human chromosome band 1q21 by in situ hybridization and radiation hybrids". Cytogenet. Cell Genet. 84 (1–2): 83–6. doi:10.1159/000015220. PMID 10343109. S2CID 10805552.
  6. ^ a b "Entrez Gene: SETDB1 SET domain, bifurcated 1".
  7. ^ Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ (April 2002). "SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins". Genes Dev. 16 (8): 919–32. doi:10.1101/gad.973302. PMC 152359. PMID 11959841.

Further reading

[edit]
[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.