Jump to content

SMEK2

From Wikipedia, the free encyclopedia
PPP4R3B
Identifiers
AliasesPPP4R3B, FLFL2, PP4R3B, PSY2, smk1, SMEK2, protein phosphatase 4 regulatory subunit 3B
External IDsOMIM: 610352; MGI: 2144474; HomoloGene: 68886; GeneCards: PPP4R3B; OMA:PPP4R3B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001122964
NM_001282850
NM_020463

NM_134034

RefSeq (protein)

NP_001116436
NP_001269779
NP_065196

Location (UCSC)Chr 2: 55.55 – 55.62 MbChr 11: 29.17 – 29.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase 4 regulatory subunit 3B is an enzyme that in humans is encoded by the SMEK2 gene.[5][6][7]

Interactions

[edit]

SMEK2 has been shown to interact with PPP4C.[8][9][5]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000275052Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020463Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity" (PDF). Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. S2CID 7531012. Archived from the original (PDF) on 2021-03-02. Retrieved 2019-09-20.
  6. ^ Chowdhury D, Xu X, Zhong X, Ahmed F, Zhong J, Liao J, Dykxhoorn DM, Weinstock DM, Pfeifer GP, Lieberman J (Jul 2008). "A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication". Molecular Cell. 31 (1): 33–46. doi:10.1016/j.molcel.2008.05.016. PMC 3242369. PMID 18614045.
  7. ^ "Entrez Gene: SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)".
  8. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  9. ^ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.

Further reading

[edit]