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SMG1

From Wikipedia, the free encyclopedia
SMG1
Identifiers
AliasesSMG1, 61E3.4, ATX, LIP, nonsense mediated mRNA decay associated PI3K related kinase, SMG1 nonsense mediated mRNA decay associated PI3K related kinase
External IDsOMIM: 607032; MGI: 1919742; HomoloGene: 56697; GeneCards: SMG1; OMA:SMG1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015092

NM_001031814
NM_177180

RefSeq (protein)

NP_055907

NP_001026984

Location (UCSC)Chr 16: 18.8 – 18.93 MbChr 7: 117.73 – 117.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene.[5][6][7][8] SMG1 belongs to the phosphatidylinositol 3-kinase-related kinase protein family.

Function

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This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.[8]

Interactions

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SMG1 (gene) has been shown to interact with PRKCI[9] and UPF1.[10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157106Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030655Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
  6. ^ Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP (June 2001). "Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein". J. Biol. Chem. 276 (25): 22709–14. doi:10.1074/jbc.C100144200. PMID 11331269.
  7. ^ Morita T, Yamashita A, Kashima I, Ogata K, Ishiura S, Ohno S (March 2007). "Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay". J. Biol. Chem. 282 (11): 7799–808. doi:10.1074/jbc.M610159200. PMID 17229728.
  8. ^ a b "Entrez Gene: SMG1 PI-3-kinase-related kinase SMG-1".
  9. ^ Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J (January 1996). "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo". Mol. Cell. Biol. 16 (1): 105–14. doi:10.1128/mcb.16.1.105. PMC 230983. PMID 8524286.
  10. ^ Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S (September 2001). "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay". Genes Dev. 15 (17): 2215–28. doi:10.1101/gad.913001. PMC 312771. PMID 11544179.

Further reading

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