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SNW1

From Wikipedia, the free encyclopedia
SNW1
Identifiers
AliasesSNW1, Bx42, NCOA-62, PRPF45, Prp45, SKIIP, SKIP, SNW domain containing 1, SKIP1, FUN20
External IDsOMIM: 603055; MGI: 1913604; HomoloGene: 56557; GeneCards: SNW1; OMA:SNW1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012245
NM_001318844

NM_025507

RefSeq (protein)

NP_001305773
NP_036377

NP_079783

Location (UCSC)Chr 14: 77.72 – 77.76 MbChr 12: 87.5 – 87.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SNW domain-containing protein 1 is a protein that in humans is encoded by the SNW1 gene.[5][6][7]

Function

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This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.[7]

Interactions

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SNW1 has been shown to interact with:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100603Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021039Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Folk P, Půta F, Krpejsová L, Blahůsková A, Markos A, Rabino M, Dottin RP (Nov 1996). "The homolog of chromatin binding protein Bx42 identified in Dictyostelium". Gene. 181 (1–2): 229–31. doi:10.1016/S0378-1119(96)00483-0. PMID 8973337.
  6. ^ a b Baudino TA, Kraichely DM, Jefcoat SC, Winchester SK, Partridge NC, MacDonald PN (Jun 1998). "Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription". The Journal of Biological Chemistry. 273 (26): 16434–41. doi:10.1074/jbc.273.26.16434. PMID 9632709.
  7. ^ a b "Entrez Gene: SNW1 SNW domain containing 1".
  8. ^ a b c d Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–47. doi:10.1128/jvi.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
  9. ^ a b Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, MacDonald PN (Nov 2001). "Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription". The Journal of Biological Chemistry. 276 (44): 40614–20. doi:10.1074/jbc.M106263200. PMID 11514567.
  10. ^ a b c Leong GM, Subramaniam N, Figueroa J, Flanagan JL, Hayman MJ, Eisman JA, Kouzmenko AP (May 2001). "Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription". The Journal of Biological Chemistry. 276 (21): 18243–8. doi:10.1074/jbc.M010815200. PMID 11278756.
  11. ^ a b c Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (Apr 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): 2400–10. doi:10.1128/mcb.20.7.2400-2410.2000. PMC 85419. PMID 10713164.
  12. ^ Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (Jun 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development. 104 (1–2): 3–20. doi:10.1016/s0925-4773(01)00373-2. PMID 11404076.
  13. ^ Kim YJ, Noguchi S, Hayashi YK, Tsukahara T, Shimizu T, Arahata K (May 2001). "The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression". Human Molecular Genetics. 10 (11): 1129–39. doi:10.1093/hmg/10.11.1129. PMID 11371506.
  14. ^ Prathapam T, Kühne C, Banks L (Dec 2002). "Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity". Nucleic Acids Research. 30 (23): 5261–8. doi:10.1093/nar/gkf658. PMC 137971. PMID 12466551.
  15. ^ Prathapam T, Kühne C, Hayman M, Banks L (Sep 2001). "Ski interacts with the evolutionarily conserved SNW domain of Skip". Nucleic Acids Research. 29 (17): 3469–76. doi:10.1093/nar/29.17.3469. PMC 55893. PMID 11522815.
  16. ^ Dahl R, Wani B, Hayman MJ (Mar 1998). "The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42". Oncogene. 16 (12): 1579–86. doi:10.1038/sj.onc.1201687. PMID 9569025.

Further reading

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