Jump to content

STEAP4

From Wikipedia, the free encyclopedia
STEAP4
Identifiers
AliasesSTEAP4, STAMP2, TIARP, TNFAIP9, STEAP4 metalloreductase, SchLAH
External IDsOMIM: 611098; MGI: 1923560; HomoloGene: 36422; GeneCards: STEAP4; OMA:STEAP4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024636
NM_001205315
NM_001205316

NM_054098

RefSeq (protein)

NP_001192244
NP_001192245
NP_078912

NP_473439

Location (UCSC)Chr 7: 88.27 – 88.31 MbChr 5: 8.01 – 8.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

STEAP family member 4 is a protein that in humans is encoded by the STEAP4 gene.[5]

Function

[edit]

The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene may be involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127954Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000012428Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: STEAP family member 4".

Further reading

[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.