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SYNJ2

From Wikipedia, the free encyclopedia
SYNJ2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSYNJ2, INPP5H, synaptojanin 2
External IDsOMIM: 609410; MGI: 1201671; HomoloGene: 117703; GeneCards: SYNJ2; OMA:SYNJ2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001178088
NM_003898

RefSeq (protein)

NP_001171559
NP_003889

Location (UCSC)Chr 6: 157.98 – 158.1 MbChr 17: 5.99 – 6.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptojanin 2 is a protein that in humans is encoded by the SYNJ2 gene.[5]

Function

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The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000078269Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023805Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Synaptojanin 2".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.