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Sodium-dependent multivitamin transporter

From Wikipedia, the free encyclopedia
SLC5A6
Identifiers
AliasesSLC5A6, SMVT, solute carrier family 5 member 6, NERIB
External IDsOMIM: 604024; MGI: 2660847; HomoloGene: 23277; GeneCards: SLC5A6; OMA:SLC5A6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021095

NM_001177621
NM_001177622
NM_177870
NM_001360022

RefSeq (protein)

NP_066918

NP_001171092
NP_001171093
NP_808538
NP_001346951

Location (UCSC)Chr 2: 27.2 – 27.21 MbChr 5: 31.19 – 31.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene.[5][6][7]

The SMVT is a transporter for pantothenic acid (vitamin B5) and biotin (vitamin B7) at the blood–brain barrier.[8] It is also a transporter for lipoic acid[9] and iodide. Transport of these nutrients is competitive[10] and a surplus of a given nutrient may saturate the transporter and prevent the uptake of other nutrients.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138074Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006641Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Prasad PD, Wang H, Kekuda R, Fujita T, Fei YJ, Devoe LD, et al. (March 1998). "Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate". The Journal of Biological Chemistry. 273 (13): 7501–6. doi:10.1074/jbc.273.13.7501. PMID 9516450.
  6. ^ Wang H, Huang W, Fei YJ, Xia H, Yang-Feng TL, Leibach FH, et al. (May 1999). "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization". The Journal of Biological Chemistry. 274 (21): 14875–83. doi:10.1074/jbc.274.21.14875. PMID 10329687.
  7. ^ "Entrez Gene: SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6".
  8. ^ Uchida Y, Ito K, Ohtsuki S, Kubo Y, Suzuki T, Terasaki T (July 2015). "Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells". Journal of Neurochemistry. 134 (1): 97–112. doi:10.1111/jnc.13092. PMID 25809983. S2CID 37721695.
  9. ^ Quick M, Shi L (2015). "The sodium/multivitamin transporter: a multipotent system with therapeutic implications". Vitamins and Hormones. 98: 63–100. doi:10.1016/bs.vh.2014.12.003. PMC 5530880. PMID 25817866.
  10. ^ Chirapu SR, Rotter CJ, Miller EL, Varma MV, Dow RL, Finn MG (31 March 2013). "High specificity in response of the sodium-dependent multivitamin transporter to derivatives of pantothenic acid". Current Topics in Medicinal Chemistry. 13 (7): 837–42. doi:10.2174/1568026611313070006. PMID 23578027.

Further reading

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