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Sperm-associated antigen 1

From Wikipedia, the free encyclopedia

SPAG1
Identifiers
AliasesSPAG1, CILD28, CT140, HSD-3.8, SP75, TPIS, HEL-S-268, sperm associated antigen 1, DNAAF13
External IDsOMIM: 603395; MGI: 1349387; HomoloGene: 8081; GeneCards: SPAG1; OMA:SPAG1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003114
NM_172218
NM_001374321

RefSeq (protein)

NP_003105
NP_757367
NP_001361250

Location (UCSC)Chr 8: 100.16 – 100.26 MbChr 15: 36.18 – 36.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sperm-associated antigen 1 is a protein that in humans is encoded by the SPAG1 gene.[5][6]

Function

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The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens.

The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa.

Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104450Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037617Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Liu N, Qiao Y, Cai C, Lin W, Zhang J, Miao S, Zong S, Koide SS, Wang L (May 2006). "A sperm component, HSD-3.8 (SPAG1), interacts with G-protein beta 1 subunit and activates extracellular signal-regulated kinases (ERK)". Frontiers in Bioscience. 11: 1679–89. doi:10.2741/1913. PMID 16368546.
  6. ^ a b "Entrez Gene: SPAG1 sperm associated antigen 1".

Further reading

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