T-cell receptor excision circles

T-cell receptor excision circles (TRECs) are small circles of DNA created in T-cells during their passage through the thymus as they rearrange their TCR genes.^[1] Their presence indicates maturation of T cells; TRECs are reduced in SCID (severe combined immunodeficiency disease).

Signal joint T-cell receptor excision circles (sjTRECs) might be used as a way to test the age of the individual from a blood sample.^[2] The detection of sjTRECs can be further used as a diagnostic tool to monitor the thymic output (e.g., following hematopoietic stem cell transplantation or in cases of AIDS).^[3]

References[edit]

^ http://allergycases.org/2010/05/t-cell-receptor-excision-circles-trecs.html^{[full citation needed]}
^ Zhang, S. L.; Bhandoola, A. (2012). "Losing TREC with age". Immunity. 36 (2): 163–165. doi:10.1016/j.immuni.2012.02.005. PMC 4026262. PMID 22365662.
^ Al-Harthi L, Marchetti G, Steffens CM, Poulin J, Sékaly R, Landay A (2000). "Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA)". Journal of Immunological Methods. 237 (1–2): 187–97. doi:10.1016/S0022-1759(00)00136-8. PMID 10725462.

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[1] ttp://allergycases.org/2010/05/t-cell-receptor-excision-circles-trecs.html^{[full citation needed]}

[2] Zhang, S. L.; Bhandoola, A. (2012). "Losing TREC with age". Immunity. 36 (2): 163–165. doi:10.1016/j.immuni.2012.02.005. PMC 4026262. PMID 22365662.

[3] Al-Harthi L, Marchetti G, Steffens CM, Poulin J, Sékaly R, Landay A (2000). "Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA)". Journal of Immunological Methods. 237 (1–2): 187–97. doi:10.1016/S0022-1759(00)00136-8. PMID 10725462.

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