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TAC4

From Wikipedia, the free encyclopedia
TAC4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTAC4, EK, HK-1, HK1, PPT-C, tachykinin 4 (hemokinin), tachykinin 4, tachykinin precursor 4
External IDsOMIM: 607833; MGI: 1931130; HomoloGene: 89219; GeneCards: TAC4; OMA:TAC4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_170685
NM_001077503
NM_001077504
NM_001077505
NM_001077506

NM_053093

RefSeq (protein)

NP_001070971
NP_001070972
NP_001070973
NP_001070974
NP_733786

NP_444323

Location (UCSC)Chr 17: 49.84 – 49.85 MbChr 11: 95.15 – 95.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tachykinin-4 is a protein that in humans is encoded by the TAC4 gene.[5][6][7]

This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1 and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176358Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020872Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhang Y, Lu L, Furlonger C, Wu GE, Paige CJ (Mar 2001). "Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis". Nat Immunol. 1 (5): 392–7. doi:10.1038/80826. PMID 11062498. S2CID 24408728.
  6. ^ Kurtz MM, Wang R, Clements MK, Cascieri MA, Austin CP, Cunningham BR, Chicchi GG, Liu Q (Oct 2002). "Identification, localization and receptor characterization of novel mammalian substance P-like peptides". Gene. 296 (1–2): 205–12. doi:10.1016/S0378-1119(02)00861-2. PMID 12383518.
  7. ^ a b "Entrez Gene: TAC4 tachykinin 4 (hemokinin)".

Further reading

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