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TBX6

From Wikipedia, the free encyclopedia
TBX6
Identifiers
AliasesTBX6, SCDO5, T-box 6, T-box transcription factor 6
External IDsOMIM: 602427; MGI: 102539; HomoloGene: 3389; GeneCards: TBX6; OMA:TBX6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004608
NM_080758

NM_011538

RefSeq (protein)

NP_004599

NP_035668

Location (UCSC)Chr 16: 30.09 – 30.09 MbChr 7: 126.38 – 126.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-box 6 is a protein that in humans is encoded by the TBX6 gene.[5]

Function

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This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures.[5]

Tbx6 is also required for the segmentation of the paraxial mesoderm into somites, and for the normal development of the dermomyotome in zebrafish. In the absence of Tbx6, the central dermomyotome of zebrafish fails to develop.[6]

Tbx6 functions in a gene regulatory network with mesp-b and ripply1.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149922Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030699Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: T-box 6".
  6. ^ Windner SE, Bird NC, Patterson SE, Doris RA, Devoto SH (Aug 2012). "Fss/Tbx6 is required for central dermomyotome cell fate in zebrafish". Biology Open. 1 (8): 806–14. doi:10.1242/bio.20121958. PMC 3507223. PMID 23213474.
  7. ^ Windner SE, Doris RA, Ferguson CM, Nelson AC, Valentin G, Tan H, Oates AC, Wardle FC, Devoto SH (Mar 2015). "Tbx6, Mesp-b and Ripply1 regulate the onset of skeletal myogenesis in zebrafish". Development. 142 (6): 1159–68. doi:10.1242/dev.113431. PMC 4360180. PMID 25725067.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.