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TPSG1

From Wikipedia, the free encyclopedia
TPSG1
Identifiers
AliasesTPSG1, PRSS31, TMT, trpA, tryptase gamma 1
External IDsOMIM: 609341; MGI: 1349391; HomoloGene: 74994; GeneCards: TPSG1; OMA:TPSG1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012467

NM_012034
NM_001357726

RefSeq (protein)

NP_036599

n/a

Location (UCSC)Chr 16: 1.22 – 1.23 MbChr 17: 25.59 – 25.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tryptase gamma, also known as serine protease 31 or transmembrane tryptase, is an enzyme that in humans is encoded by the TPSG1 gene.[5]

Function

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Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116176Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033200Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: tryptase gamma 1".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.