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TRIM55

From Wikipedia, the free encyclopedia

TRIM55
Identifiers
AliasesTRIM55, MURF-2, RNF29, muRF2, tripartite motif containing 55
External IDsOMIM: 606469; MGI: 3036269; HomoloGene: 13205; GeneCards: TRIM55; OMA:TRIM55 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_033058
NM_184085
NM_184086
NM_184087

NM_001081281

RefSeq (protein)

NP_149047
NP_908973
NP_908974
NP_908975

NP_001074750

Location (UCSC)Chr 8: 66.13 – 66.18 MbChr 3: 19.7 – 19.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tripartite motif-containing protein 55 is a protein that in humans is encoded by the TRIM55 gene.[5][6]

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147573Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060913Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Centner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S (Mar 2001). "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain". J Mol Biol. 306 (4): 717–26. doi:10.1006/jmbi.2001.4448. PMID 11243782.
  6. ^ a b "Entrez Gene: TRIM55 tripartite motif-containing 55".

Further reading

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