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TRNASer (uridine44-2'-O)-methyltransferase

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TRNASer (uridine44-2'-O)-methyltransferase
Identifiers
EC no.2.1.1.211
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

TRNASer (uridine44-2'-O)-methyltransferase (EC 2.1.1.211, TRM44) is an enzyme with systematic name S-adenosyl-L-methionine:tRNASer (uridine44-2'-O)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + uridine44 in tRNASer S-adenosyl-L-homocysteine + 2'-O-methyluridine44 in tRNASer

The 2'-O-methylation of uridine44 contributes to stability of tRNASer(CGA).

References

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  1. ^ Kotelawala L, Grayhack EJ, Phizicky EM (January 2008). "Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species". RNA. 14 (1): 158–69. doi:10.1261/rna.811008. PMC 2151035. PMID 18025252.
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