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MCOLN2

From Wikipedia, the free encyclopedia
(Redirected from TRPML2)
MCOLN2
Identifiers
AliasesMCOLN2, TRP-ML2, TRPML2, mucolipin 2, mucolipin TRP cation channel 2
External IDsOMIM: 607399; MGI: 1915529; HomoloGene: 12258; GeneCards: MCOLN2; OMA:MCOLN2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_153259
NM_001330647

NM_001005846
NM_026656

RefSeq (protein)

NP_001317576
NP_694991

NP_001005846
NP_080932

Location (UCSC)Chr 1: 84.93 – 85 MbChr 3: 145.86 – 145.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mucolipin-2 also known as TRPML2 (transient receptor potential cation channel, mucolipin subfamily, member 2) is a protein that in humans is encoded by the MCOLN2 gene.[5] It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.

TRPML2 is associated with the Arf6-regulated trafficking pathway and is involved in the intracellular transport of membranes and membrane proteins.[6]

See also

[edit]
  • transient receptor potential cation channel, mucolipin subfamily, member 1 (MCOLN1)
  • transient receptor potential cation channel, mucolipin subfamily, member 3 (MCOLN3)
  • TRPML

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153898Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000011008Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
  6. ^ Karacsonyi C, Miguel AS, Puertollano R (October 2007). "Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs". Traffic. 8 (10): 1404–14. doi:10.1111/j.1600-0854.2007.00619.x. PMID 17662026. S2CID 25624298.
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