Talk:Brachytherapy/Archive 1

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Archive 1

Removed?

I am wondering, does anyone know whether the radioactive seeds used in Prostate Brachytherapy remain in-situ when the rods/catheters are removed after the three or so treatments?144.137.250.17 15:27, 31 January 2007 (UTC)

Do you mean with Interstitial HDR Prostate Brachy? They are removed - the source is attached to the end of the wire. I believe there is a seed implantation method of brachy too - my department doesn't perform that one so I don't know about that one (I'm a computer guy working in a radonc dept, so I only know what I pick up from the physicists :-) --Surturz 04:25, 1 February 2007 (UTC)

Seeds remain in situ for prostate brachtherapy as they release a constant dose rate over time (several months) to the prostate. The half life of I-125 is around 2 months. Typically we implant maybe 100 tiny seeds per patient sometimes deep inside the prostate. They are around 4 mm long so retrieving them after they have done the job may be a little tricky! They will decay over time and present no external hazard outside the skin of the patient. HDR brachy therapy however uses much higher dose larger sources which are designed to give a dose of radiation over a much shorter time. Hope this helps.194.176.105.40 14:31, 27 February 2007 (UTC)

With intercavity brachy (for cervical cancer) are the seeds removed does anyone know? putting them in has been discussed but i forgot to ask about having them removed / or do they degrade naturally?

As far as I know, for cervical cancer an applicator is used to guide wired seeds from the remote afterloader to the correct place. 212.123.177.139 12:17, 2 May 2007 (UTC)
There are two types of treatment offered for cervical cancer, both low-dose and high-dose. In low-dose brachy the "seed(s)" usually won't stay in play for more than 72 hours. It is usually supplemented with external beam therapy (in preparation) and requires a short hospital stay. Hope that answers your question. --Ronin

I had low-dose seeds implanted in my prostate about 10 years ago. The seeds come in sets of nine seeds connected by a wire. I had 11 sets or 108 seeds implanted. The only side-effect is that I occasionally spat out a seed--often painful. Also, I have an occasional expulsion of a drop of blood every couple of months, even now. 69.121.226.166 (talk) 21:02, 5 October 2016 (UTC) Tholzel

Jeffrey Musmacher

I removed the following "There is a device that was made widely acceptable by Jeffrey Musmacher in New York that uses this applicator to successfully treat skin cancers. He has published about 8 papers on this treatment modality." I did a google search for Jeffrey Musmacher and it looks like he is indeed an oncologist but we need a reference to go with this new material. -- Ronin

I added in a blurb about Jeffrey Musmacher after I found a few references to back it up. ----Ronin103 (talk) 23:02, 28 January 2008 (UTC)

Jargon

What is a "stat dose?" Sounds like jargon. —Preceding unsigned comment added by 63.125.124.226 (talk) 20:55, 16 December 2008 (UTC)

Spelling

I am sometimes seeing the spelling "brachytheraphy." Is this a typo? Or is it legit? Or does it have some slightly different meaning? —Preceding unsigned comment added by 71.167.13.137 (talk) 17:41, 21 April 2009 (UTC)

Pretty sure that's a typo my friend.

Talk:Brachytherapy/Archive 1/GA1

"Glioblastoma multiforme and other brain tumors" section removal

I deleted this entire section:

Glioblastoma multiforme and other brain tumors

The following extracts from a Thursday, August 4, 2011 online news release are from Richmond, Virginia, from the News Office of Virginia Polytechnical Institute and State University (Virginia Tech, whose main campus is in Blacksburg, Virginia). They concern research, using murine (mice) animal models, in brachytherapy done by Michael D. Shultz, John D. Wilson, Dr. Christine E. Fuller, Jianyuan Zhang, Harry C. Dorn, and Panos P. Fatouros at Virginia Tech and at Virginia Commonwealth University (VCU) toward the relief of certain malignant brain tumors, including glioblastoma multiforme, the deadliest form of brain cancer. The research is published in the August 2011 issue of the medical journal "Radiology", ahead of print August 3 (the title is "Metallofullerene-based Nanoplatform for Brain Tumor Brachytherapy and Longitudinal Imaging in a Murine Orthotopic Xenograft Model").

"A single compound with dual function- the ability to deliver a diagnostic and therapeutic agent-may one day be used to enhance the diagnosis, imaging, and treatment of brain tumors...tumor cells often extend beyond the well-defined tumor margins making it extremely difficult for clinicians and radiologists to visualize with current imaging techniques...the study...demonstrated that a nanoparticle containing an MRI (magnetic resonance imaging) diagnostic agent can effectively be imaged within the brain tumor and provide radiation therapy in an animal model. Survival of the treated mice was 2.5 times longer than the untreated mice (52 days compared to 20.7 days). The nanoparticle filled with gadolinium, a sensitive MRI contrast agent for imaging, and coupled with radioactive lutetium 177 to deliver brachytherapy, is known as a theranostic agent- a single compound capable of delivering simultaneously effective treatment and imaging. The lutetium 177 is attached to the outside of the carbon cage of the nanoparticle. The researchers report three advances in knowledge..."

For the rest of the report, go to:

<<http://www.vtnews.vt.edu/articles/2011/08/080411-research-dornradiology.html>>

A copied and pasted press release does not belong in the list of clinical applications. Or as its own section anywhere, in fact. A write-up of brachytherapy brain cancer treatments could be a nice addition to the article, but an abridged abstract of a single paper does not a good section make. Kolbasz (talk) 19:30, 19 September 2011 (UTC)

History

The beginning of the history section is extremely poor. The claims in the first sentence are nonsensical and not supported by ref. 16 (the paper by V. Gupta). Ref. 17 was a webpage without source notes that is no longer available (except in the Internet Archive). I have added an external link to my research note on the beginnings of brachytherapy, in case anyone wants to correct this. 2003:63:C77:AF4F:141E:8DEA:48C6:F84B (talk) 14:01, 8 August 2015 (UTC) F.S. Litten

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WP:SELFCITE

This article went through a major rewrite in 2008 by User:Rock_mc1 who disclosed on their user page that "Edits performed to the brachytherapy article on the 15th November 2009 were made with the support of Prof. F Guedea, Nucletron B.V. and other experts." and the massively cited Gerbaulet, Alain; Pötter, Richard; Mazeron, Jean-Jacques; Meertens, Harm; Limbergen, Erik Van, eds. (2002). The GEC ESTRO handbook of brachytherapy. Leuven, Belgium: European Society for Therapeutic Radiology and Oncology. ISBN 978-90-804532-6-5. ack. Jytdog (talk) 07:01, 2 June 2016 (UTC)

based on worldcat this is not a widely held book. see here. I'll be rewriting this from other sources. Jytdog (talk) 07:09, 2 June 2016 (UTC)

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Methods of Breast Brachytherapy

@Jytdog Hi Jytdog. I noticed you recently removed a portion of one of my edits for lacking sources. I've since re-added it with sources added. If what's written now is still inadequate, could you reply to me here so I have an opportunity to address the concerns? When I get around to it, I'll likely attempt the same for NIBB as well (i.e. re-add with appropriate refs). If I could make the same request there I'd appreciate it.

Cheers, 

J.michael7 (talk) 00:20, 21 September 2017 (UTC)

Request edit on 3 April 2018

Non-Invasive Breast Brachytherapy Non-Invasive Breast Brachytherapy (NIBB) has the advantage of delivering radiation to the tumor bed without needing an invasive device. This is accomplished by employing external applicators with breast immobilization and mammographic image guidance for each radiation treatment fraction. The complications of managing an indwelling catheter or catheters are eliminated, as are the risks of instrumentation-related infection. Also, oncoplastic reconstruction to enhance the cosmetic outcomes of surgery can be performed with NIBB as long as the tissues at risk are appropriated marked. The dose to healthy tissues (heart, lungs, skin, and chest wall) is minimized through the use of shielded applicators which position and direct the radiation field([1]). Non-Invasive Breast Brachytherapy currently being used for APBI([2]) and the "boost” portion([3]) of EBRT.


This edit belongs under the breast cancer brachytherapy section. Ekimyenoom (talk) 15:43, 4 April 2018 (UTC)

References

  1. ^ Sioshansi, S; Rivard, M; Hiatt, J; Hurley, A; Lee, Y; Wazer, D (2011). "Dose modeling of noninvasive image-guided breast brachytherapy in comparison to electron beam boost and three-dimensional conformal accelerated breast irradiation". Int J Radiat Oncol Biol Phys. 80 (2): 410-416.
  2. ^ Hepel, JT; Hiatt, JR; Sha, S; Leonard, KL; Graves, TA; Wiggins, DL; Mastras, D; Pittier, A; Wazer, DE (2014). "The rationale, technique, and feasibility of partial breast irradiation using noninvasive image-guided breast brachytherapy". Brachytherapy. 13: 493-501.
  3. ^ Hepel, JT; Leonard, KL; Hiatt, JR; DiPetrillo, TA; Wazer, DE (2014). "Factors influencing eligibility for breast boost using noninvasive image-guided breast brachytherapy". Brachytherapy. 13: 579-583.

Reply quotebox with inserted reviewer decisions and feedback 04-APR-2018

Below you will see where text from your request has been quoted with individual advisory messages placed underneath, either accepting, declining or otherwise commenting upon your proposal(s). Please see the enclosed notes for additional information about each request. Also note areas where additional clarification was required. When this clarification is ready to be provided to the reviewer, please change the edit request template to read from ans=yes to ans=no.  Spintendo      16:45, 4 April 2018 (UTC)

Non-Invasive Breast Brachytherapy Non-Invasive Breast Brachytherapy (NIBB) has the advantage of delivering radiation to the tumor bed without needing an invasive device. This is accomplished by employing external applicators with breast immobilization and mammographic image guidance for each radiation treatment fraction. The complications of managing an indwelling catheter or catheters are eliminated, as are the risks of instrumentation-related infection. Also, oncoplastic reconstruction to enhance the cosmetic outcomes of surgery can be performed with NIBB as long as the tissues at risk are appropriated marked.
Red X Not approved.[note 1]
___________

The dose to healthy tissues (heart, lungs, skin, and chest wall) is minimized through the use of shielded applicators which position and direct the radiation field([1]). Non-Invasive Breast Brachytherapy currently being used for APBI([2]) and the "boost” portion([3]) of EBRT.
exclamation mark  Clarification needed.[note 2]
___________

  1. ^ These claims are unreferenced.
  2. ^ These references have been given page ranges. Please provide the specific page numbers where the information is located.
User:Spintendo thanks for replying, but your response here was off.
The 2nd note about page numbers is not really relevant -- we dont need them for journal articles (for books, yes), but not for journal articles.
The real issue here are the sources. The first ref is PMID 20646854, the second is PMID 24997723, and the third is PMID 25129613. All three of these refs fail WP:MEDRS in that they are primary sources. Both Spintendo and Ekimyenoom, please review WP:MEDRS and especially WP:MEDDEF. These are "primary sources" in that they are papers describing clinical trials. What MEDRS says, is that content about health needs to be sourced to "secondary sources", which are literature reviews in good quality journals in the biomedical literature, or statements by major medical or scientific bodies (the NIH, the NHS in the UK, the FDA or EMA, NICE in the UK, guidelines by mainstream medical associations, and the like). The content is not OK because the sources cited are not reliable per MEDRS.
Further the content is really marketing the medical device, with some citations thrown behind it. Using Wikipedia for promotion is not OK, per the policy, WP:PROMO. What we do is summarize what reliable sources say and we look at what several MEDRS refs say, and give emphasis as they do.
This is a hard thing to learn how to do, and more difficult when a person's job is to market something. But this is Wikipedia, and this is how we work here. Jytdog (talk) 17:16, 4 April 2018 (UTC)

No mention of plaque brachytherapy for uveal melanoma

Uveal melanoma says " The most common radiation treatment is plaque brachytherapy, in which a small disc-shaped shield (plaque) encasing radioactive seeds (most often iodine-125, though ruthenium-106 and palladium-103 are also used) is attached to the outside surface of the eye, overlying the tumor. " - We should mention here - so plaque brachytherapy can redirect to it ? - Rod57 (talk) 23:43, 27 January 2022 (UTC)

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