Talk:Chemotherapy-induced peripheral neuropathy

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Can we try to say something about the mechanism

What are the theories or explanations of CIPN ? - Why are some agents more associated with CIPN ? Are some agents more associated with some of the sub-types of CIPN ? Has there been anything written about how to prevent it (before or during chemo) ? - Rod57 (talk) 13:21, 19 June 2017 (UTC)[reply]

Since we have a Research section we should also describe current medical practice ?

Female Cancer Survivors Face Years of Neuropathy. 2017 includes a link to the current practice (Prevention and Management of CIPN ... ASCO guidelines 2014) which seems only to recommend duloxetine for treatment. Maybe there are more recent US/EU recommendations. - Rod57 (talk) 13:28, 19 June 2017 (UTC)[reply]

Agree that we should add a section on current practice. As a cancer patient, my observation is that most doctors are candid about the current high risk for permanent peripheral neuropathy with platinum-based chemotherapy and the inadequate nature of most proposed treatments or preventative measures. The best that seems to be done is to reduce the dosing of platinum-based agents in certain circumstances. David Spector (talk) 17:37, 22 August 2017 (UTC)[reply]

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Cold Therapy added

This new section should be self-explanatory, but feel free to ask questions about the 2016 pilot study. David Spector (talk) 17:32, 22 August 2017 (UTC)[reply]

We don't add single studies that way - if we did WP would be a cluttered mess full of false leads. Please use reviews per WP:MEDRS Jytdog (talk) 00:31, 23 August 2017 (UTC)[reply]

Thank you for correcting my edit. I was not familiar with this policy, and I appreciate learning about it. Just one question: if this pilot study is replicated or corroborated by additional peer-reviewed studies in the future, do these additional citations allow including the information in the article, or must there truly be a metastudy or citation in a book to corroborate the phenomenon? Are all peer-reviewed studies really considered "false leads"? Seems like a very severe policy if multiple studies are also disallowed. David Spector (talk) 00:40, 23 August 2017 (UTC)[reply]

Hm... it is not really about the number of studies. It is really a question of whether there is a "phenomenon" to discuss at all. Biomedical research is very difficult, and there are many small pilot studies like this that never get more money put into them to see if they actually work (so we never know) and many that do get tested in big enough, well-enough-designed studies, turn out not to work at all. But the important thing is that we don't judge for ourselves. What MEDRS discusses, is that we let experts in the field tell us what works -- we find that information in a) literature reviews published in good quality journals, and b) statements by major health bodies, like the FDA, the NIH, NICE or NHS in the UK, etc. MEDRS explains this pretty well. I started an essay (that others have worked on but still needs a lot of work) called WP:Why MEDRS? that tries to explain why we source health content this way. The extended lead is all you really need out of that. If you like. :) Jytdog (talk) 07:05, 23 August 2017 (UTC)[reply]

Acetyl-L-carnitine

Another 2013 review (or is this the same study, just 2 different papers?) indeed saw that Acetyl-L carnatine worsened conditions for people with Taxane-caused CIPN, but it did provide relief for those with cisplatin-caused CIPN. ^[1]

Should we change the article?

Lacreighton (talk) 12:45, 23 April 2018 (UTC)[reply]

References

^ Schloss, Janet M.; Colosimo, Maree; Airey, Caroline; Masci, Paul P.; Linnane, Anthony W.; Vitetta, Luis (2013-12-01). "Nutraceuticals and chemotherapy induced peripheral neuropathy (CIPN): a systematic review". Clinical Nutrition (Edinburgh, Scotland). 32 (6): 888–893. doi:10.1016/j.clnu.2013.04.007. ISSN 1532-1983. PMID 23647723.

[1] Schloss, Janet M.; Colosimo, Maree; Airey, Caroline; Masci, Paul P.; Linnane, Anthony W.; Vitetta, Luis (2013-12-01). "Nutraceuticals and chemotherapy induced peripheral neuropathy (CIPN): a systematic review". Clinical Nutrition (Edinburgh, Scotland). 32 (6): 888–893. doi:10.1016/j.clnu.2013.04.007. ISSN 1532-1983. PMID 23647723.

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