Talk:Collision-induced dissociation

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Mass spectrometry (inactive)

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This article was automatically assessed because at least one WikiProject had rated the article as stub, and the rating on other projects was brought up to Stub class. BetacommandBot 09:46, 10 November 2007 (UTC)[reply]

I moved the rating up to Start class. --Kkmurray (talk) 18:58, 26 March 2008 (UTC)[reply]

Expanding article

Would anyone have any objection to me making some changes to this page? (1) I'd like to add a section for conventional ion-trap CID as this is a very common technique, but materially different to tandem mass spectrometry in a triple quad. In particular, because it usually (always?) uses resonant activation of the precursor ion, it is less likely to create fragments-of-fragments, giving simpler product spectra, that vary less with increased energy. These differences are practically relevant. (2) I'd like to rename Triple quadrupole mass spectrometers >> "Tandem mass spectrometers", explaining that triple-quadrupoles are a sub-set and the traditional name, but nowadays many instruments use a collision cell between Q1 and Q3 that is not itself a quadrupole. The name has stuck, but the design has moved on - not terribly important, but worth noting. (3) Given that I'm mentioning triples and ion-traps, I think it worth mentioning the difference between tandem-in-space and tandem-in-time. I'm thinking this is best done in the two sections, triple-quad and ion-trap. (4) I'd like to add to the mechanism paragraph, some mention about CID being (generally) low-energy and slow, and therefore more liable to form fragments after internal rearrangements, as compared to electron ionization, where it's more of a statistical process. CID forms fragments that are energetically favoured, while higher-energy methods can form fragments that are kinetically favoured. (Oops, must remember to use US spellings when I do it though. Favored.) (5) Some of this is easily referenced from other sources, but some isn't. I'm wondering if I should just write and reference what I can, and let the community judge whether the remainder needs references adding, or should be deleted as unreferenenceable personal writing.

Any thoughts about whether this is appropriate, or comments on things I ought to include/omit please post, otherwise I'll do it. 149.155.219.44 (talk) 14:13, 12 February 2015 (UTC)[reply]

There should be discussion of trap/in-time vs. in-space (triple quad, QTOF, sector, TOF/TOF). There also should be a discussion of high vs. low-energy CID (and HCD, MS^E). And in-source CID and general reactions in plasmas not necessarily related to MS. --Kkmurray (talk) 15:44, 12 February 2015 (UTC)[reply]

Where does the information "HCD is High-energy CID" come from? This appears to be marketing speech. It is definitely not high-energy CID; in fact, TOF (in-space) CID spectra and Orbi HCD spectra look very, very similar at the same eV.