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first paragraph is unclear

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As a chemistry undergraduate with above average knowledge of biology, I didn't understand the first paragraph , it feels like the article is only for those who already know what a consensus sequence is. As far as I understand a consensus sequence is a series of bases in which certain bases have a higher frequency than others, usually this sequence is a binding site for a protein, as explained in a later paragraph starting "A consensus sequence may be...". Whmice (talk) 14:34, 10 February 2009 (UTC)[reply]

Better?

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The introduction is very precise which gives it a lot of strength. Nevertheless, I agree that it isn't written for the lay-person and may an insufficient sufficient guide for understanding the concept. Perhaps something like this would be better:

  • I went ahead in changed it from: In molecular biology and bioinformatics, consensus sequence refers to the most common nucleotide or amino acid at a particular position after multiple sequences are aligned. A consensus sequence is a way of representing the results of a multiple sequence alignment, where related sequences are compared to each other, and similar functional sequence motifs are found. The consensus sequence shows which residues are most abundant in the alignment at each position.

References

  1. ^ Pierce, Benjamin A. 2002. Genetics : A Conceptual Approach. 1st ed. New York: W.H. Freeman and Co.
  2. ^ Pierce, Benjamin A. 2002. Genetics : A Conceptual Approach. 1st ed. New York: W.H. Freeman and Co.

Something to Add

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I think it would be beneficial to have a short sequence example. It might be beneficial to show several aligned sequences and then show the consensus sequence; nothing extravagant; something simple. Hopefully will do this weekend. Dlpolanco (talk) 22:23, 8 May 2012 (UTC)[reply]

Biological significance should be first

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I think the biological significance should be first in the article. The computational aspect doesn't have any meaning or context without the biology. If anyone has any further comment on this change or on the order of content in general, drop a line here. — Preceding unsigned comment added by Rustyfence (talkcontribs) 04:59, 8 April 2014 (UTC)[reply]

Please clarify

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"On the contrary, mutations that destroy [conserved] nucleotides in the consensus sequence are known as down mutations." Why do you say "conserved" nucleotides here? If it mutates, it's by definition not conserved, right? Why not just leave the word "conserved" out and not raise confusing questions in the reader's mind. This entry is jargony enough for even modestly non-expert readers as it is.

Also agree with rustyfence above.

Eperotao (talk) 16:03, 12 November 2015 (UTC)[reply]

Clarification on example

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It says that Y can stand for any pyrimidine; IIUC from the linked article (and I may well not!), a pyrimidine can be C, T, or U. Given that we're told this is a DNA sequence, U is out. Doesn't that make [CT] mean the same thing as Y?

I would suggest either an example that doesn't use both [CT] and Y, or an explanation of the difference (or simply a confirmation that they're equivalent). — Preceding unsigned comment added by Luke Maurer (talkcontribs) 04:34, 22 February 2016 (UTC)[reply]

Assessment comment

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The comment(s) below were originally left at Talk:Consensus sequence/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

Changed rating to "high" as this is important for molecular biology (promoters) and bioinformatics (DNA pattern recognition). The article needs to be expanded to include biological significance (e.g. binding sites for transcription factors) and examples (e.g. TATA box) etc. - tameeria 22:46, 18 February 2007 (UTC)[reply]

Last edited at 22:46, 18 February 2007 (UTC). Substituted at 12:12, 29 April 2016 (UTC)