Talk:FOXP3

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Update to structure of article?

The contents and structure of this page are a bit confused. Might an alternative structure to enhance clarity be a good idea? Possible headings: Structure, Function, Mechanism of action, Relevance (with subheadings: Role in autoimmunity, Role in cancer), Interactions. This structure would be similar to chaperone protein Hsp90.Phytat (talk) 14:59, 25 February 2016 (UTC)[reply]

Where is it found in the cell

Article says it is a transcription factor so it probably spends some time floating in the nucleus - but does it spend time outside the nucleus ? and what regulates its level or activity ? and what shape is it ? - Rod57 (talk) 02:54, 19 December 2012 (UTC)[reply]

Article confuses the molecule 'Foxp3' and regulatory T cells that are Foxp3+

This article contains sections about regulatory T cells, which express Foxp3 and is frequently not specifically about Foxp3 the molecule. Work needs to be done to disambiguate content on regulatory T cells and the molecule Foxp3.Phytat (talk) 12:38, 31 January 2016 (UTC)[reply]

Reference for first paragraph

A good article that reviews the origins and role of regulatory T cells.^[1]Phytat (talk) 12:38, 31 January 2016 (UTC)[reply]

Scurfin reference

The article refers to the FOXP3 as also being known as Scurfin in the first line, but this is not referenced until later in the article. This term is not in common use any more so really it is questionable whether it should be referred to in the first line of the article. I suggest that ^[2] is used to reference the term Scurifin in the first paragraph as this is one the key articles in the discovery of the function of the FOXP3 gene. This reference is currently number 4 in the references list for the article. - Phytat (talk) 16:41, 1 June 2015 (UTC)[reply]

More accurate referencing of T regulatory cell development and function?

Currently the article refers to ^[3] as the primary review article in the first paragraph. It would be better perhaps to refer to primary articles that first showed how FOXP3 programs the development and function of regulatory T cells? These articles are currently referenced later in a less accurate way ^[4]^[5]^[6]. - Phytat (talk) 16:41, 1 June 2015 (UTC)[reply]

References for CD4 T cell lineage plasticity

Currently references 9 and 10 in the article are incomplete ^[7]^[8]. These references could be updated to references that more closely match the topic ^[9]^[10]^[11]. I suggest that ^[9] could be used as the reference for the unreferenced section at the end of the the physiology paragraph. - Phytat (talk) 16:41, 1 June 2015 (UTC)[reply]

References

^ Josefowicz SZ., Lu L-F, and Rudensky AY (January 2012). "Regulatory T Cells: Mechanisms of Differentiation and Function". Annu Rev Immunol. 30 (January): 531–64. doi:10.1146/annurev.immunol.25.022106.141623. PMID 22224781.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F (January 2001). "Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse". Nat. Genet. 27 (1): 68–73. doi:10.1038/83784. PMID 11138001.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Zhang L, Zhao Y (June 2007). "The regulation of Foxp3 expression in regulatory CD4(+)CD25(+)T cells: multiple pathways on the road". J. Cell. Physiol. 211 (3): 590–597. doi:10.1002/jcp.21001. PMID 17311282.
^ Hori S, Nomura T, Sakaguchi S (February 2003). "Control of regulatory T cell development by the transcription factor Foxp3". Science. 299 (5609): 1057–61. doi:10.1126/science.1079490. PMID 12522256.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Fontenot JD, Gavin MA, Rudensky AY (April 2003). "Foxp3 programs the development and function of CD4+CD25+ regulatory T cells". Nat. Immunol. 4 (4): 330–6. doi:10.1038/ni904. PMID 12612578.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY (March 2005). "Regulatory T cell lineage specification by the forkhead transcription factor foxp3". Immunity. 22 (3): 329–41. doi:10.1016/j.immuni.2005.01.016. PMID 15780990.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Romagnani
^ Stockinger
^ ^a ^b Zhou L, Chong MM, Littman DR (May 2009). "Plasticity of CD4+ T cell lineage differentiation". Immunity. 30 (5): 646–655. doi:10.1016/j.immuni.2009.05.001. PMID 19464987.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Bluestone JA, Mackay CR, O’Shea JJ, Stockinger B (November 2009). "Effector T cell plasticity: flexibility in the face of changing circumstances". Nature Reviews. 9 (11): 811–816. doi:10.1038/nri2654. PMID 19809471.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Murphy KM, Stockinger B (August 2010). "The Functional Plasticity of T Cell Subsets". Nature Immunology. 11 (8): 674–680. doi:10.1038/ni.1899. PMID 20644573.

Ribbon Diagram Image?

Does anyone have a ribbon diagram of this that could be used? Jimw338 (talk) 05:24, 14 July 2015 (UTC)[reply]

[Josefowicz_2012-1] Josefowicz SZ., Lu L-F, and Rudensky AY (January 2012). "Regulatory T Cells: Mechanisms of Differentiation and Function". Annu Rev Immunol. 30 (January): 531–64. doi:10.1146/annurev.immunol.25.022106.141623. PMID 22224781.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[Brunkow_2001-2] Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F (January 2001). "Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse". Nat. Genet. 27 (1): 68–73. doi:10.1038/83784. PMID 11138001.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid17311282-3] Zhang L, Zhao Y (June 2007). "The regulation of Foxp3 expression in regulatory CD4(+)CD25(+)T cells: multiple pathways on the road". J. Cell. Physiol. 211 (3): 590–597. doi:10.1002/jcp.21001. PMID 17311282.

[pmid12522256-4] Hori S, Nomura T, Sakaguchi S (February 2003). "Control of regulatory T cell development by the transcription factor Foxp3". Science. 299 (5609): 1057–61. doi:10.1126/science.1079490. PMID 12522256.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid12612578-5] Fontenot JD, Gavin MA, Rudensky AY (April 2003). "Foxp3 programs the development and function of CD4+CD25+ regulatory T cells". Nat. Immunol. 4 (4): 330–6. doi:10.1038/ni904. PMID 12612578.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid15780990-6] Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY (March 2005). "Regulatory T cell lineage specification by the forkhead transcription factor foxp3". Immunity. 22 (3): 329–41. doi:10.1016/j.immuni.2005.01.016. PMID 15780990.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[7] Romagnani

[8] Stockinger

[pmid19464987-9] Zhou L, Chong MM, Littman DR (May 2009). "Plasticity of CD4+ T cell lineage differentiation". Immunity. 30 (5): 646–655. doi:10.1016/j.immuni.2009.05.001. PMID 19464987.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid19809471-10] Bluestone JA, Mackay CR, O’Shea JJ, Stockinger B (November 2009). "Effector T cell plasticity: flexibility in the face of changing circumstances". Nature Reviews. 9 (11): 811–816. doi:10.1038/nri2654. PMID 19809471.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid20644573-11] Murphy KM, Stockinger B (August 2010). "The Functional Plasticity of T Cell Subsets". Nature Immunology. 11 (8): 674–680. doi:10.1038/ni.1899. PMID 20644573.

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