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This article was automatically assessed because at least one WikiProject had rated the article as stub, and the rating on other projects was brought up to Stub class. BetacommandBot07:53, 10 November 2007 (UTC)[reply]
From what I have gleaned, the long duration is becauae of the high cLogP and metabolism is via N-dealkylation of the piperidine ring. I have readf about serious side-effects in primates so I would like to know if it's use as a potential medication is checked with a low oral dose before depot.... or someone is going to be seriously ill for a month. — Preceding unsigned comment added by 81.99.74.135 (talk) 15:27, 7 May 2017 (UTC)[reply]
If the 8 position has an α-methyl benzyl or 2-(2-thienyl)-benzyl group then it has sub-nanomole affinity for the NOP receptors. — Preceding unsigned comment added by 81.99.74.135 (talk) 13:37, 29 July 2017 (UTC)[reply]