Talk:Glycerol-3-phosphate dehydrogenase

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EC-numbers[edit]

cytosolic 1.1.1.8
mitochondrial (using Q): 1.1.5.3

It is logical that the NAD-dependent is a different enzyme than the FAD-dependent one. So obviously, some databases are not that correct. --Yikrazuul (talk) 17:46, 29 May 2010 (UTC)[reply]

I agree that a quinol-dependent enzyme is a different from a NAD-dependent one. However you have not provided a source that states that GPD1 is quinol dependent while GPD2 is NAD dependent. Are Brenda, OMIM, and UniProt that have all classified GPD1 as a 1.1.1.8 enzyme all wrong? Boghog (talk) 00:06, 30 May 2010 (UTC)[reply]

OK, they are different:

GPD1 (cytoplasmic) → 1.1.1.8
GPD2 (mitochondrial) → 1.1.5.3

But the assignment was reversed from what it should have been. I have fixed it in this edit. Boghog (talk) 01:42, 30 May 2010 (UTC)[reply]

reaction mechanism[edit]

The GPD2 reaction mechanism seems to be out of order, or at least not rigorously accurate. It shows FAD being 'reduced' by 2 protons yet remaining electrically neutral, before the hydride ion even leaves the G3P. And then the hydride, which doesn't appear in the mechanism, magically becomes a free proton.

173.25.54.191 (talk) 19:28, 22 March 2014 (UTC)[reply]

Duplicate page?[edit]

I've found this page: https://en.wikipedia.org/wiki/Glycerol-3-phosphate_dehydrogenase_(quinone) and I think it describes (with a lot fewer details) exactly the same enzyme. Shouldn't that page there be deleted? Linuxo (talk) 09:36, 8 May 2018 (UTC)[reply]