Talk:KRAS

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Function

I think a specific example illustrating the function would be very helpful. (For example, a demonstration of the role of KRAS in the best-studied function.) Is there a way to formally request something like this from domain experts? Neuroschizl (talk) 00:28, 2 May 2016 (UTC)[reply]

KRAS positive

CLinical significance section says EGFR inhibitors are effective against most wild-type KRAS negative [colon] cancers, but what treatments are targeted at the mutated KRAS (positive) cancers ? Rod57 (talk) 13:35, 15 November 2010 (UTC)[reply]

KRAS positive treatments follow a typical surgery and chemotherapy path, without the further options of biological therapies/monoclonal antibodies. —Preceding unsigned comment added by 193.63.217.208 (talk) 17:01, 17 November 2010 (UTC)[reply]

See the Ras Targeted Therapies section in the general Ras family article which is linked at the top of this article. That section should be expanded since a lot of different approaches have been tried and a lot of research is going on in this area. Farnesyltransferase inhibitors (like Salirasib) really only work on HRAS an not KRAS. Another approach is to target the pathway immediately below RAS, especially RAF or MEK. Sorafenib (a RAF inhibitor), for example, is in clinical trials against KRAS lung cancers. Another possibility in clinical trials for some late stage KRAS cancers are immune therapies targeting CTLA4 or PD-1 (which have nothing to do with KRAS, as such.) There is nothing effective targeted specifically and directly at KRAS so far. — Preceding unsigned comment added by 130.132.88.91 (talk) 19:17, 20 March 2013 (UTC)[reply]

Requested update

Hi,

My name is Carole Welsch and i am Associate Director, Personalized Heathcare at QIAGEN Inc. I would like to contribute to this page and share some recent information that will help update the KRAS Wikipedia page to make it more accurate. In July 2012, the FDA approved a companion diagnostic KRAS test for the drug Erbitux. As a consequence, the drug label was updated to require the use of an FDA approved KRAS test prior to prescribing the drug. Therefore, i would like to suggest the following addition to the existing page. For your convenience, i have also referenced each statement with third party source.

Under the “KRAS testing” section which currently reads: “In July 2009, the US Food and Drug Administration (FDA) updated the labels of two anti-EGFR monoclonal antibody drugs (panitumumab (Vectibix) and cetuximab (Erbitux)) indicated for treatment of metastatic colorectal cancer to include information about KRAS mutations.[17]”

I would like to suggest adding: “In 2012, the FDA also cleared QIAGEN’s therascreen KRAS test, which is a genetic test designed to detect the presence of seven mutations in the KRAS gene in colorectal cancer cells. This test is used to aid physicians in identifying patients with metastatic colorectal cancer for treatment with Erbitux. The presence of KRAS mutations in colorectal cancer tissue indicates that the patient may not benefit from treatment with Erbitux. If the test result indicates that the KRAS mutations are absent in the colorectal cancer cells, then the patient may be considered for treatment with Erbitux.”

[Reference: http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/DeviceApprovalsandClearances/Recently-ApprovedDevices/ucm312055.htm]

I look forward to hearing back from you. Best regards,

Carole

Carolewelsch (talk) 20:11, 26 November 2012 (UTC)[reply]

seems ok. Added as above Wiki CRUK John (talk) 11:16, 20 June 2014 (UTC)[reply]

Image

PDB in picture is not KRas. It is farnesyltransferase with 11 residues of Kras as the substrate, — Preceding unsigned comment added by 141.211.201.244 (talk) 06:01, 27 May 2014 (UTC)[reply]

You are right. Seems like nobody noticed until even now. I've just created a 3D rendering of KRAS (based on PDB ID 3GFT) and put it in the infobox. SPLETTE :] ^{How's my driving?} 05:22, 16 November 2016 (UTC)[reply]

Pronunciation

I think it would be useful to include a pronunciation of the word 'KRAS'. I have heard it pronounced as both KAY-ras and as kras, one syllable. We use the former. It would help prevent misunderstandings. Kernos (talk) 15:14, 2 July 2014 (UTC)[reply]

Agreed. I added something to address this. My understand is that all of the Ras family genes follow the guideline: first constant, followed by RAS. For example H-ras, K-ras, N-ras. Neuroschizl (talk) 00:24, 2 May 2016 (UTC)[reply]

External links modified

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Clinical significance when mutated

KRAS is mentioned in some papers like https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745605/ for its association with low grade serous ovarian carcinoma, it should be added.

Waiting for a secondary source (reviewed articles)..

If a mutated version of the protein KRAS is pulled to the surface of cancer cells, then the drug-KRAS complex acts as an "eat me" flag that marks cancer cells for destruction by the immune system.^[1] 82.50.120.164 (talk) 09:19, 19 September 2022 (UTC)[reply]

References

^ "Drug Turns Cancer Gene Into 'Eat Me' Flag for Immune System". UCSF. September 13, 2022. doi:10.1016/j.ccell.2022.07.005. PMID 36099883. Retrieved September 16, 2022.

[1] "Drug Turns Cancer Gene Into 'Eat Me' Flag for Immune System". UCSF. September 13, 2022. doi:10.1016/j.ccell.2022.07.005. PMID 36099883. Retrieved September 16, 2022.

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