Talk:Lung cancer susceptibility

Medicine: Hematology-oncology / Pulmonology Mid‑importance

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Nicotinic Receptor/Acetylcholine Receptor

Nicotinic and Acetylcholine Receptor Subunits

Cholinergic receptors that form a ligand-gated ion channels in the plasma membranes of certain neurons and on the postsynaptic side of the neuromuscular junction, as inotropic receptors. nAChRs are linked to ion channel and do not use second messengers. They activate the proliferation, apoptosis and tumor invasion, single nucleotide polymorphisms spanning the nAChRs encoding genes cluster CHRNA3/A5/B4 with both nicotine dependence and lung cancer incidence and susceptibility. Prolonged or repeated exposure to stimulus often results in decrease responsiveness of that receptor toward a stimulus, termed desensitization. nAChR function can be modulated by phosphorylation, the activation of second messengers dependent protein kinases. Cholinergic receptor CHRNA3 is also known as nicotinic, alpha 3 (neuronal) gene with a protein product. Cholinergic receptor CHRNA5 Is also known as nicotinic, alpha 5 (neuronal) gene with a protein product, located also in the chromosome 15q24. Both subunits are related to lung cancer.^[1]

Smoking Cases

The smoking cases are related to the nicotinic and acetylcholine receptor receives the nicotinic from the cigarettes, and stimulates the neurons. These affect the gene expression when it codes wrong, it releases genes and increase the risk of lung cancer. ^[2]

^ McKay, J.D. (2008). "Lung Cancer susceptibility Locus at 5p15.33". Genetics. 1: 10. Retrieved 19 April 2013.

^ Hung, R.J. (2008). [hurl=https://www.clinicalkey.com/#!/ContentPlayerCtrl/doPlayContent/2-s2.0-18385738/%7B%22scope%22:%22all%22,%22query%22:%22Lung%20cancer%20susceptibility%20locus%20at%205p15.33.%22%7D "L susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25"]. Genetics. 1: 10. Retrieved 19 April 2013. {{cite journal}}: Check |url= value (help)

was removed wholesale, along with some significant, content-removing other changes because they "did not make sense at all". I post them here so that someone who is familiar with the subject can improve them. WhatamIdoing (talk) 18:20, 23 May 2013 (UTC)[reply]

[McKay-1] McKay, J.D. (2008). "Lung Cancer susceptibility Locus at 5p15.33". Genetics. 1: 10. Retrieved 19 April 2013.

[Hung-2] Hung, R.J. (2008). [hurl=https://www.clinicalkey.com/#!/ContentPlayerCtrl/doPlayContent/2-s2.0-18385738/%7B%22scope%22:%22all%22,%22query%22:%22Lung%20cancer%20susceptibility%20locus%20at%205p15.33.%22%7D "L susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25"]. Genetics. 1: 10. Retrieved 19 April 2013. {{cite journal}}: Check |url= value (help)

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