Talk:Methohexital

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Methohexital.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Untitled

The following information is from DrugBank, and should be rewritten (not copied!) into the article.

CITATIONS

This article does not cite any sources!!! —Preceding unsigned comment added by 71.204.15.239 (talk) 20:08, 2 May 2008 (UTC)[reply]

The statement that is it a barbiturate does not seem to need a source as the structure is given... —Preceding unsigned comment added by 92.234.76.73 (talk) 22:30, 28 February 2009 (UTC)[reply]

Pharmacology

Methohexital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.

Toxicity

The onset of toxicity following an overdose of intravenously administered methohexital will be within seconds of the infusion. If methohexital is administered rectally or is ingested, the onset of toxicity may be delayed. The manifestations of an ultrashort-acting barbiturate in overdose include central nervous system depression, respiratory depression, hypotension, loss of peripheral vascular resistance, and muscular hyperactivity ranging from twitching to convulsive-like movements. Other findings may include convulsions and allergic reactions. Following massive exposure to any barbiturate, pulmonary edema, circulatory collapse with loss of peripheral vascular tone, and cardiac arrest may occur.

Structure

I've removed File:Methohexital-3D-balls.png from the article, as the methyl group on nitrogen has been omitted by accident. The same problem affects File:Methohexital-3D-spacefill.png. The correct structure can be downloaded as a PDB file from my website: http://www.benjamin-mills.com/chemistry/structures/methohexital-from-xtal-2003.pdb. This is the structure of the S_bR_h stereoisomer as determined by X-ray crystallography and reported in Eur. J. Org. Chem. (2003) 5, 855–862. --Ben (talk) 22:03, 24 December 2011 (UTC)[reply]