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Archive 1

Juxtamedullary region

The juxtamedullary region is formed between the thick ascending limb of the loop of Henle and the afferent arterioles; not the DCT and the afferent arterioles. This article as it stands is incorrect. ICL - 10:49 April 13, 2007 (UofA)

Are you speaking of the juxtaglomerular apparatus by chance? (I ask because the JG apparatus is entirely different from the juxtamedullary region; the latter is the cortical region directly abutting the renal medulla.) If so, I completely agree, so I've corrected the article. Feel free to make these sorts of changes in the future -- after all, this is a wiki! Greetings from the past, David Iberri (talk) 00:01, 15 April 2006 (UTC)

Proximal tubule

Why doesn't proximal tubule have its own article? 203.218.86.162 14:46, 6 June 2006 (UTC)

It does. --David Iberri (talk) 22:20, 5 December 2006 (UTC)

Aquaporins

Are now fully accepted by being the mechaisms for water resorption in the collecting ducts and if I remember correctly, the DLOH too. Why not included? AELangford 02:34, 9 June 2007 (UTC)

Probably because other more specific articles are better equipped to discuss the detailed mechanisms of water and solute absorption in the nephron. See collecting duct system, vasopressin, and related articles. Speaking of related articles, I think we need a water homeostasis article. --David Iberri (talk) 16:32, 10 June 2007 (UTC)

Photo

I think the second photo in this article should not be in a language other than english. This is an english article. —Preceding unsigned comment added by 65.184.165.46 (talk) 18:07, 7 September 2007 (UTC)

-- agreed. —Preceding unsigned comment added by 83.141.126.213 (talk) 14:12, 13 April 2008 (UTC)

yup, i got confused too for a second. --Lynntyler (talk) 03:42, 23 October 2008 (UTC)

I made an effort to update some of the labels in English, but grew bored with the task unfortunately. :-) I've exchanged out the Polish version of the image with another drawing of the nephron with English labels (Image:Renal Diuretics.gif). Hopefully this is an improvement. --David Iberri (talk) 01:47, 24 October 2008 (UTC)

Uniferous tubule

I was redirected to this page on a search for "uniferous tubule," but could not find any information on it. Can someone knowledgable about this topic add a reference to explain what a uniferous tubule is? Wakablogger2 (talk) 22:23, 5 October 2010 (UTC)

Defination of nephron

each capillary clusterin the kidney is associated with a the cup shaped end of tube that collects the filtered urine. this filteration unit is called nephron.1.38.16.237 (talk) 12:56, 22 June 2013 (UTC)

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Lead rewrite

I have rewritten the Lead for accuracy, completeness, and clarity. It has been reverted with the justification that the former Lead was better and the new one has sentences that are too long.

I am displaying the former and new Leads here. I welcome discussion on what specifically in the new Lead is inaccurate or needs editing. I will go into detail regarding the defects in the old Lead if needed.

CURRENT - 5 sentences The nephron (from Greek νεφρός – nephros, meaning "kidney") is the basic structural and functional unit of the kidney.[1] Its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood, reabsorbing what is needed and excreting the rest as urine. A nephron eliminates wastes from the body, regulates blood volume and blood pressure, controls levels of electrolytes and metabolites, and regulates blood pH. Its functions are vital to life and are regulated by the endocrine system by hormones such as antidiuretic hormone, aldosterone, and parathyroid hormone.[2] In humans, a normal kidney contains 800,000 to 1.5 million nephrons.[3] IiKkEe (talk) 21:22, 6 September 2017 (UTC)

update - I have reentered my revised Lead in thirteen separate steps with justifications for each edit, and it has thus far gone unchallenged. So far so good. IiKkEe (talk)

Help with reducng image please

I have posted the following outrageously large image under Juxtaglomerular apparatus in hopes I can get assistance with reducing it to an appropriate size, and add the description under it. I haven't figured out how to do this myself. If no one reduces it I will remove it.

Image:Glomerular Physiology.png|Glomerulus

Description: Cross-sectional diagram of the juxtaglomerular apparatus and adjacent structures: 1) top, yellow - distal convoluted tubule; 2)top,brown -macula densa, cuboidal cells surrounding arterioles; 3) small blue cells - juxtaglomerular cells; 4) large blue cells - mesangial cells; 5) tan - podocytes lining Bowman’s capsule adjacent to capillaries, and parietal layer of capsule: 6)center - five glomerular capillaries, and 6)bottom, purple - exiting tubule.

Can anyone help? Thanks. IiKkEe (talk) 15:01, 7 September 2017 (UTC)

File:Kidney nephron molar transport diagram.svg

Confusing text in the last part of "clinical significance" paragraph

I don't understand what is meant by the following text. It is in my opinion meaningless:

"However, this clinical significance raises many concerns about treatments to such medical conditions. Because diuretics are drugs that stimulate the body's metabolism to higher intensities, primarily stimulating the heart, the clinical significance creates minor controversy considering how individuals with high blood pressure would avoid introducing medications that raise their already high blood pressure." 93.51.235.135 (talk) 13:27, 26 June 2017 (UTC)

I deleted this section: unreferences and inaccurate. IiKkEe (talk) 18:07, 7 September 2017 (UTC)

Disagreement on definition of nephron

Iztwoz has questioned whether the word "structural" belongs in the 1st sentence of this article, and has requested a citation to document it is part of the definition . To me this is self evident: we have an image in the Lead showing its unique structure; and we have a section in the article titled Structure. I'm not going to put a citation in the Lead - that's not ever required - but I'll put a few dictionary references here for now. Perhaps whatever editor wrote the Structure section should be asked to document with a reference that the structure of the nephron is unique, and an inherent part of what defines it. I don't have access to either a Guyton or a Seldin textbook - a reference from one of those should settle the issue on the definition.

For now: from http://medical-dictionary.thefreedictionary.com/Nephrons nephron (redirected from Nephrons) Also found in: Dictionary, Thesaurus, Encyclopedia. nephron [nef´ron]: the structural and functional unit of the kidney...

Nephron from http://www.biology-online.org/dictionary/Nephron Home » Nephron Definition: The structural and functional unit of the kidney, i.e. a structure comprised of a set of tubules and its chief functions are blood filtration, osmoregulation, and waste elimination by urine formation...

Regards IiKkEe (talk) 17:00, 12 September 2017 (UTC)

Hi IiKkEe not sure if I can contribute constructively to this page, but it is sometimes helpful to include citations in the lead (particularly for medical and anatomical articles) as this can help alleviate some contention. I am also surprised about this statement "whatever editor wrote the structure section" - you must know multiple editors contribute to articles over many years here on WP. --Tom (LT) (talk) 12:02, 13 September 2017 (UTC)
Tom (LT) Thanks for your input. Thanks to Iztwoz

for explaining to me why he added the reference to the Lead. I think we're all working together now. Regards -- IiKkEe (talk) 12:41, 13 September 2017 (UTC)

Recent edits and summaries

Hi, IiKkEe - I don't understand your dictating of the terms of editing of the article. It is only a C rated page at the moment - there is a lot of work needed to improve the page. There is a lot of material that is in the lead and not in the body - and a lot of this is too much detail for the lead. It is not a golden rule that the lead not contain citations - it has happened here because as mentioned there is material here that is not in the body - when it is all sorted refs can be adjusted if necessary. The ref i inserted was to the use of the phrase since i had previously removed it. Instead of repeatedly reverting my edits can you make more constructive ones. cheers --Iztwoz (talk) 06:29, 13 September 2017 (UTC)

--Iztwoz Thanks for your reply, your spirit of cooperation, and explanation of the reference. I thought I was following the "edit-revert-discuss" process: I'll be careful in the future. You're right about references in the Lead: I reviewed WPMOS - they're preferred in the Body and discouraged, but not forbidden, in the Lead. I put your reference in 3 places under Structure: please delete them if the reference doesn't support the statement. I think we're in the same place now: hoping you can pitch in on making the Body better. Regards IiKkEe (talk) 12:22, 13 September 2017 (UTC)
@User:IiKkEe Have removed figure numbers from infobox and lead - did you check the appropriateness of their inclusion in the lead. They are fine in the body of text which is where most of the detail of the page needs to be.--Iztwoz (talk) 10:54, 18 September 2017 (UTC)
For example there are seven references to Bowman's capsule in the lead and only four in the body. cheers --Iztwoz (talk) 10:58, 18 September 2017 (UTC)

@Iztwoz Good point: I never thought about not using figure numbers in the Lead. Thanks for your sharp eye. Also appreciate your feed-back they are fine with you in the Body. Regards IiKkEe (talk) 12:48, 18 September 2017 (UTC)

References

Verifiability is one of the five pillars of Wikipedia. To help readers verify this article, and (in my experience) protect the article from incorrect changes, this article is in great need of some references (eg textbooks, journal articles)... Happy to offer any help with formatting references if needed. --Tom (LT) (talk) 21:54, 28 September 2017 (UTC)

I agree. This article is extremely important. I've provided book references from 3 books for all 15 instances of "citation needed". Dr. Vogel (talk) 15:50, 12 April 2020 (UTC)

Renal tubule

Men Like 197.250.197.201 (talk) 16:15, 28 September 2022 (UTC)

Lead Section

The lead section of this page seems like it should be broken up between the lead section and the article body. Approaching this from a layman view, the introduction is currently disjointed and contains a level of depth better suited for later sections. Below is a proposed restructuring of the lead section excluding details I would move to the body. Wiki newbie here, so any fact checking or advice appreciated. Currently lacking in citations, as the first paragraph of the current page already seems to be. I believe some of the clarifications are answered throughout the article, but truthfully I rearranged this much so I could understand it, and the finer details can be a project for someone with a greater interest.

The nephron is the minute or microscopic structural and functional unit of the kidney. A healthy adult has 1 to 1.5 million nephrons in each kidney[4]: 22 . The job of each nephron is to filter blood into urine. Each nephron is composed of a renal corpuscle and a renal tubule. The renal corpuscle consists of a tuft of capillaries called a glomerulus and a cup-shaped structure called Bowman's capsule. The renal tubule has peritubular capillaries running between the descending and ascending portions of the tubule. Both the Bowman's capsule and renal tubule are composed of epithelial cells with a lumen.
The filtration is performed through three layers: the endothelial cells of the capillary wall, its basement membrane, and between the foot processes [clarification needed] of the podocytes of the lining of the capsule. As the fluid [clarification needed] from the capsule flows down into the tubule, it is processed by the epithelial cells lining the tubule: water is reabsorbed and substances [clarification needed] are exchanged; first with the interstitial fluid outside the tubules, and then into the plasma in the adjacent peritubular capillaries through the endothelial cells lining that capillary. This process regulates the volume of body fluid as well as levels of many body substances. At the end of the tubule, the fluid exits as urine composed of water, metabolic waste, and toxins.

Thespacesay (talk) 08:17, 14 June 2023 (UTC)

References

  1. ^ Pocock, G. Human Physiology.Oxford University Press.Third edition.2006. Page 349.
  2. ^ Maton, Anthea; Jean Hopkins; Charles William McLaughlin; Susan Johnson; Maryanna Quon Warner; David LaHart; Jill D. Wright (1993). Human Biology and Health. Englewood Cliffs, New Jersey, USA: Prentice Hall. ISBN 0-13-981176-1.
  3. ^ Guyton, Arthur C.; Hall, John E. (2006). Textbook of Medical Physiology. Philadelphia: Elsevier Saunders. p. 310. ISBN 0-7216-0240-1.
  4. ^ Lote CJ (2012). Principles of Renal Physiology (5th ed.). Springer.

Depth

The mechanisms in the loop of Henle are rather complicated. In my opinion, they are beyond the scope of this article. I will add more details to the loop of Henle article. Axl 12:00, 2 Dec 2004 (UTC)

Article subtitle

I'm not sure how to change this, but I thought it relevant to let it be known that this article's subtitle when appearing on a search engine is labelled as "Food." Please let this be deleted when someone manages to correct the subtitle.

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