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Talk:Phosphoinositide 3-kinase

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Untitled

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Would it not be simpler to use the abbreviation PI3K? It is now used in most publications, it is unambigous and easier to type. — Preceding unsigned comment added by Klausokken (talkcontribs) 11:11, 28 January 2006 (UTC)[reply]

Clean-up

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This article is growing from a little stub into a fully grown piece, but needs a little bit of formatting and tidying up to help it along.....so I added in the clean-up tag Ciar 06:17, 11 December 2006 (UTC)[reply]

Wikipedia Cell Signaling Project

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Should this article be incorporated into the wikipedia cell signaling project? (http://en.wikipedia.org/wiki/Wikipedia:WikiProject_Cell_Signaling) The involvement of PI3K seems to be important in signalling PKB activation, and probably a whole lot of other proteins. --Sinkingpie 00:07, 23 January 2007 (UTC)[reply]

It is as important as Rho GTPases or MAP Kinases in global cell signalling, so I would say yes Mammal4 09:00, 23 January 2007 (UTC)[reply]
PI3K signalling appears to be incorporated very heavily into a lot of cell biology.
It has been shown to be activated on response to T cell antigen, Cytokines, Growth Factors, Heterotrimeric and small G proteins, Tyrosine Kinases and probably many more.
And the products, PIP, PIP2 and PIP3 have been shown to affect:
DNA synthesis, Cell survival, Membrane ruffling, Oxidative burst, chemotaxis, cytoskeletal rearrangements, oocyte maturation, receptor internalisation, glucose transport, vesicle trafficking. --JamMan 14:51, 8 May 2007 (UTC)[reply]

Phosphatidylinositol 3-kinase or Phosphoinositide 3-kinase

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Which is correct, I'd go for the former as that's its substrate but no one's picked up on this yet so...--JamMan 14:52, 8 May 2007 (UTC)[reply]

Phosphoinositide 3-kinase is correct as PI3Ks can phophorylate PtdIns(4,5)P2 in addition to phosphatidylinositol itself. Phosphoinositide is used as a generic term to refer to all the different phosphorylated variants. —Preceding unsigned comment added by Klausokken (talkcontribs) 09:28, 23 January 2008 (UTC)[reply]

Figure is mislabelled

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Figure is mislabelled, structure is of PI3k gamma not alpha — Preceding unsigned comment added by 66.150.13.138 (talk) 23:10, 13 July 2007 (UTC)[reply]

my bad. thanks for catching it. Roadnottaken 04:54, 14 July 2007 (UTC)[reply]

PTEN

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PTEN is not a oncogene —Preceding unsigned comment added by 24.8.43.71 (talk) 15:28, 3 May 2009 (UTC)[reply]

Rm'd stuff from the intro

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Hi folks, I removed a section from the intro that was drawn from the paper "Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes", about the inhibitory effects of certain compounds on PI3Ks. I guess that someone inserted this when they were stoned as a joke. To right the balance, I am removing it while I am stoned. This definitely doesn't belong in the intro, and it seems confusing and distracting to the article in general. Graft | talk 17:38, 16 August 2012 (UTC)[reply]

Add information

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Maybe need add information:
Ayyadevara S, Alla R, Thaden JJ, Shmookler Reis RJ. (2008). Remarkable longevity and stress resistance of nematode PI3K-null mutants. Aging Cell; 7, 13 - 22; doi: http://dx.doi.org/10.1111/j.1474-9726.2007.00348.
217.29.16.249 (talk) 13:49, 5 January 2015 (UTC)[reply]

Per WP:MEDRS, secondary sources and human data are necessary to backup medical claims. The following source is primary and only contains animal studies:
* Ayyadevara S, Alla R, Thaden JJ, Shmookler Reis RJ (2008). "Remarkable longevity and stress resistance of nematode PI3K-null mutants". Aging Cell. 7 (1): 13–22. doi:10.1111/j.1474-9726.2007.00348.x. PMID 17996009.{{cite journal}}: CS1 maint: multiple names: authors list (link)
The following source is better although it still deals with only animal studies:
Boghog (talk) 14:30, 5 January 2015 (UTC)[reply]

Copanlisib-label

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FDA pretty clear in Copanlisib-label, referring to Phosphatidylinositol 3-kinase — Preceding unsigned comment added by Wowbagger2 (talkcontribs) 21:49, 3 October 2017 (UTC)[reply]