Talk:Plasma cell

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I[edit]

I deleted the following text from the text since it is incorrect. B-cells are indeed professional Antigen-presenting cells and therefore need to have MHCII. See the article on B-cells. If the user who wrote this has a better source, please let us know.../Eribro 21:35, 13 November 2006 (UTC)[reply]

WARNING!The content on this page is INCORRECT! Consult a different source. B-cells DO NOT HAVE MHCIIs=--macrophages do. B-cells ARE NOT phagocytic.

The source which you cite is ALSO incorrect. As I stated in the discussion for the B-cells article:

The second paragraph regarding the 2nd paragraph in "The Ancestry of B-cells" should be deleted, or a second reference should be cited.

The Nature Immunology 2006 paper referenced (Li et al) DOES NOT state that mammalian B-cells are capable of/activated following antigen phagocytosis. Trout and frogs are not mammals. MALIGNANT (not normal) mammalian B-lymphocytes acquire phagocytic capability, implying a common ancestry for APCs and B lymphocytes in mammals.

130.219.4.164 (talk) 23:45, 30 January 2008 (UTC)Anonymous Med Student[reply]

I was under the impression that B-Cells became plasma and memory cells at the germinal center. This article states the B-Cells become the germinal center. This article contradicts the article on germinals centers; however, I don't know if B-Cells become three different cells or if the number mentioned erroniously counted the germinal center.

-Franco Healy —Preceding unsigned comment added by Fdhealy (talk • contribs) 22:13, 7 October 2009 (UTC)[reply]

Half the story[edit]

We seem to have an ongoing problem with this article. Plasma cells (in humans) generally (not always) arise in the spleen. What is the precursor cell? An undifferentiated B cell. Where did that B cell come from? The bone marrow.

So do plasma cells come from the spleen or the bone marrow? The answer is "both" -- or just the bone marrow, if you're talking about a person with no spleen. I'll see whether I can find some decent sources and explain this so that neither group of thoughtless or ill-informed editors will continue asserting that their favorite half of the story is the whole story. WhatamIdoing ([[User talk:WhatambbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjjkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkbbjkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkjbbbbbbbbbbbbbbbbbbbbbbbbbbbbbkkkkkkkkkkkkkkkkkkkkkkkkkkkkkbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbkuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuukkkkkkkkbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkIdoing|talk]]) 01:05, 12 June 2009 (UTC)[reply]

The picture of malignant PC's[edit]

Can anyone explain what I see in the picture with the caption: "Malignant plasma cells (plasmacytoma), with the characteristic "clockface nuclei" seen in normal plasma cells." Which ones are the normal cells (if any) and which the malignant ones? — Preceding unsigned comment added by Aoosten (talk • contribs) 00:42, 19 December 2010 (UTC) clockface nuclei ones are normal.-med school histo class. —Preceding unsigned comment added by 98.163.227.209 (talk) 01:05, 25 February 2011 (UTC)[reply]

contradctn[edit]

2factrsafeguard?Differentiation through a T cell-independent antigen stimulation (stimulation of a B cell that does not require the involvement of a T cell) can happen anywhere in the body[2] and results in short-lived cells that secrete IgM antibodies81.11.207.191 (talk) 17:09, 22 November 2016 (UTC)[reply]