Talk:Protandim/Archives/2011/April
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Desensitization
I see a potentially dangerous side effect of long-term protandim use. My concern relates to the long-term regulation of the antioxidant genes involved with protandim. To simplify my concern I will specifically speak of Superoxide dismutase (SOD). My concern is this. If someone were to take protandim for many years, at some point downregulation may occur to bring the cellular concentrations of SOD back to its natural levels (example - downregulation of nrf2). Then if that person were to stop their regiment of the protandim, the cellular concentrations of SOD would drop below natural levels, for some period of time, until the gene is correctively upregulated to return back to its natural concentrations again. During this period of time when SOD is below natural levels the person involved would have inadequate protection from oxidative stress. I recently had a correspondence with Joe McCord where I asked him if there are any peer-reviewed papers that even touch on the relationship of protandim to downregulation, desensitization, or drug tolerance to which he answered 'no'. —Preceding unsigned comment added by Br1answanson (talk • contribs) 21:25, 25 May 2010 (UTC)
- Mitochondrial free-radical theory of aging (MFRTA) is widely questioned. The Lifevantage web site presents it as well-established and accepted when that is anything but the case. Affecting nrf2 may be useful in promoting a healthy aging process, but much more research is needed. It appears that they have yet to test the effect of Protandim on the life span of any animal species. It seems like that would be something that one would be ethically obligated to do before promoting a formula for life extension purposes in humans.
Glutathione supplementation may indeed extend lifespan. http://www.rimkor7.com/gsh_healthy_aging.php Protandim has been shown to cause really significant up-regulation of glutathione in cell studies. (300% in 24 hr. period). Sparing quantities of protandim along with a cysteine donor such as whey protein may serve as an effective regimen for managing glutathione metabolism to promote healthy aging. However, it would be a low-impact long-term approach. Using it for a long period of time and then stopping may indeed cause various problems. (Entropy7 (talk) 18:52, 10 June 2010 (UTC))
- FYI DR Hall Mrs qauck buster is a fraud and is not a doctor by any means. Go ahead and look up her past and how she became a so called expert doctor and you will have quite a laugh. she knows nothing when it comes to any of these studies and is not qualified in any aspect to give any type of feed back period. —Preceding unsigned comment added by 173.210.119.102 (talk) 02:58, 4 April 2011 (UTC)
- If you question the reliablity of a source's credentials then you had best be putting some evidence on the table. If you don't have any, then your comment should probably be withdrawn. It's inappropriate to blindly slander sources (eg, calling Hall "a fraud").Rhode Island Red (talk) 15:43, 4 April 2011 (UTC)
- FYI DR Hall Mrs qauck buster is a fraud and is not a doctor by any means. Go ahead and look up her past and how she became a so called expert doctor and you will have quite a laugh. she knows nothing when it comes to any of these studies and is not qualified in any aspect to give any type of feed back period. —Preceding unsigned comment added by 173.210.119.102 (talk) 02:58, 4 April 2011 (UTC)