Talk:Solenoid protein domain

Potential need for expansion

I thank you for all the clarifications made to this article: it really improves clarity. Two sub-sections might still be worthwhile to add in the near future: one on the genetics and evolution of solenoid domains (e.g. the repeats themselves and the mechanisms involved in repeat expansions, such as inequal cross-over, gene fusions, etc.). This figure could be a good illustration for that section. Another section to be considered is a concise list of all the better known solenoid domains (classified by architecture, length, topology, etc). To be frank, I lack a level of expertise on this field to delve that deep into this topic. But if anyone of you feel ready for it: just start editing! Bubus (talk) 00:19, 23 January 2013 (UTC)

Multiple sequence alignment

You might want to consider inserting this figure as an example of a sequence repeat leading to a solenoid structure. Alexbateman (talk) 14:34, 21 January 2013 (UTC)

Example multiple sequence alignment of a pentapeptide repeat leading to a solenoid structure

Good idea. It could also be combined with a figure showing the solenoid structure. --Quantum7 10:50, 12 March 2018 (UTC)

Solenoid used too generally here

I'm pretty familiar with the literature around this article, and I think that "solenoid protein" is being used too broadly in the current version. Generally it is restricted to proteins where the backbone follows a roughly superhelical fold. For instance, see the review by Kobe and Kajava. This would include families like leucine-rich repeats, ankyrin repeats, and HEAT domains, but not examples like WD40 where the repeats have compact, complex topologies.

The more general term for the folds discussed is internal symmetry. I would suggest that the article either be split in two, or else renamed to something generic like internal symmetry in proteins of which solenoid proteins would be one example.

--Quantum7 15:25, 14 February 2018 (UTC)

Protein tandem repeats

I agree that the term "solenoid" is used too generally here, as it usually refers only to extended (open) protein tandem repeats. Closed (circular) protein tandem repeats are a different class according to Kajava's classification. The information itself is valid and valuable, it should just be shifted to the more general Protein tandem repeats page, keeping the solenoid page only for the "true" (i.e. elongated) solenoids. SilvioTosatto (talk) 19:14, 31 July 2020 (UTC)

Splitting content

The "solenoid" page is being split into three parts, corresponding to the three major branches of Kajava's classification. This page will retain the "elongated" solenoids, while the "closed/circular" ones are migrated to Toroid repeat proteins. Similar work will be needed for "beads on a string" repeats. Once the work is complete, the relevant sections from this page will be removed. SilvioTosatto (talk) 15:48, 1 August 2020 (UTC)

References