Talk:Waardenburg syndrome

Medicine: Dermatology / Genetics Low‑importance

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Waardenburg syndrome.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

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This article was the subject of a Wiki Education Foundation-supported course assignment, between 22 January 2020 and 30 April 2020. Further details are available on the course page. Student editor(s): Thavan24.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 12:35, 17 January 2022 (UTC)[reply]

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Untitled

Basic observation - Melanin plays an important part of coloration of the skin, the hair, the eyes, and structures in the inner ear. This syndrome is a side-effect of underproduction of melanin (not to outright albino characteristics), therein this defect is also a defect in a duplicate gene-copy of the Melanin production synthesis. It could be like Tay-Sachs in that the resulting molecular end product is a non-functional Melanin or Eumelanin variation. If you regard the Biosynthetic pathways in the Melanin production, then this could also be a defect which breaks the production chain of Neuromelanin.

It is also logical to assume that since Melanin variations (in regards to cellular production capacity) are important in skin coloration, hair coloration, that multiple copies of these important genes exist in the chromosomes and that copy defects or copy absence results in hair / skin coloration variety. This syndrome points to a Biosynthetic pathway problem in a specific genetic location. — Preceding unsigned comment added by 24.247.218.8 (talk) 13:13, 9 November 2011 (UTC). Signature added by SUM1 (talk) 7 January 2020[reply]

Response to above statement: I believe there are two aspects to the phenotype of coloured skin showing. One is the production of melanin, the other is the melanocytes that contain the melanin. In Waardenburg Syndrome, melanocytes appear to be a requirement for hearing, whether or not they contain melanin. Eltimbalino (talk) 09:00, 27 May 2017 (UTC)[reply]

Unreliable Source Review Request has been Made

I have made a request for the statement about 75% of exotic marked ferrests' reference to be reviewed.

Wikipedia:Reliable_sources/Noticeboard#Waardenburg_syndrome - Other_animals - WP:SPS

If it doesn't stand up, I'll remove the statement from the Other Animals section. Eltimbalino (talk) 08:48, 27 May 2017 (UTC)[reply]

No activity occurred on the unreliable source review request, so I deleted the dubious and poorly referenced sentence. Eltimbalino (talk) 04:04, 1 July 2017 (UTC)[reply]

No such thing as genex or not, be/can be any no matter what. — Preceding unsigned comment added by Lyhendl (talk • contribs) 11:32, 1 September 2018 (UTC)[reply]